Retinal OCTA to detect tiny blood vessel problems in people with MINOCA

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will use optical coherence tomography angiography (OCTA) of the retina to compare microvascular parameters across three matched groups: patients with MINOCA, patients with acute coronary syndrome (ACS) with obstructive coronary disease, and healthy controls. Matching will be done for age, sex, left ventricular ejection fraction at admission, and chronic kidney disease stage to reduce confounding. Within the MINOCA group the study will look for differences between clinical subtypes (for example Takotsubo syndrome, vasospastic angina, microvascular angina, and cases with plaque erosion) to explore possible mechanisms. Retinal microvascular metrics will be analyzed to see whether they differ between groups and whether they predict outcomes in MINOCA patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: Patients aged \> 18.

Diagnosis:

MINOCA Group: Patients diagnosed with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) confirmed by coronary angiography.

ACS Group: Patients with Acute Coronary Syndrome (ACS) with significant coronary artery stenosis which are matched with MINOCA patients for gender, age, LVEF at admission and chronic kidney disease stage.

Healthy Controls: Age and gender-matched healthy individuals with no history of cardiovascular disease.

Consent: Written informed consent obtained from all participants. Feasibility: Ability to undergo OCTA and other required imaging procedures.

Exclusion Criteria:

* Ocular Conditions: Any significant ocular disease (e.g., glaucoma, diabetic retinopathy, macular degeneration) that could interfere with OCTA imaging quality.

Severe Comorbidities: Presence of severe systemic diseases, such as advanced renal failure, active cancer, or severe liver disease, which might impact study participation.

Coronary Artery Disease or Myocarditis: For the MINOCA group, patients with coronary artery stenosis \> 50% or functionally significant (FFR \<0.8) or patients with Myocarditis detected through CMR will be excluded Pregnancy: Pregnant or breastfeeding women. Inability to Comply: Patients unable or unwilling to comply with study procedures, including follow-up visits.

Where it's running

• University of Pisa, Cisanello Hospital
  Pisa, Pisa, Italy Recruiting

Study contacts

• Study coordinator: Mattia Alberti, Dr
• Email: mattia.alberti96@outlook.it
• Phone: +393271946335

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.