Restoring social connection to prevent repeat suicide attempts with VIGILANS
Official title: Prevention of Suicidal Behavior Through the VIGILANS Protocol: the Restoration of Social Connection Hypothesis
Run by University Hospital, Montpellier · NCT05227183 · Data updated 2026-11-12
This project will test whether responses to a virtual social stress task can reveal biological, cardiac, and emotional differences that predict which adults in VigilanS will make another suicide attempt.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 55 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 1 site (Montpellier) |
| Status | Recruiting |
| Started | September 12, 2024 |
| Main results expected | March 13, 2027 |
| Study ends | September 13, 2027 |
| Registry record updated | October 2, 2025 |
| Trial ID | NCT05227183 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–55 who are enrolled in the VigilanS program at CHU Montpellier or Nîmes, speak French, can consent, and have a documented prior suicide attempt are eligible.
✕Probably not a fit
People outside the 18–55 age range, not enrolled in VigilanS, unable to complete the virtual stress task, or who do not speak French are unlikely to benefit from participating.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will recruit 120 adults enrolled in the VigilanS program who previously attempted suicide and split them into two groups of 60 based on whether they had a repeat attempt during the six-month VigilanS monitoring. All participants will complete a virtual Trier Social Stress Test (V-TSST) while investigators measure cortisol, alpha-amylase, inflammatory markers, and heart rate variability, and collect self-reports of social support and loneliness. The study will also test social cognition performance and relate these measures to suicidal recurrence during monitoring and over an additional six-month follow-up. The protocol is multicentric, involves minimal risk, and uses standardized biological and psychophysiological measurements to compare the two groups.
Why it matters
Potential benefit: If successful, the approach could help identify people at high risk of repeat suicide attempts so clinicians can offer earlier, targeted social-support interventions.
How similar studies have gone: Prior research has linked social stress responses, inflammation, and suicide risk and has used TSST-type tasks, but using a virtual TSST to predict suicide relapse within VigilanS is a relatively novel application.
Who can join: the full rules
Show full inclusion / exclusion criteria
For all subjects: * Patients benefiting from VigilanS monitoring at CHU Montpellier / Nîmes * aged between 18 and 55 years old; * able to understand experimental procedures * able to speak, read and understand French * able to give written informed consent Specific inclusion criteria: TS+: Had an actual suicide according to C-SSRS suicidal recurrence during the 6 months prior to VigilanS TS-: Had not suffered a suicidal recurrence during the 6 months prior to VigilanS
Where it's running
-
Maude SENEQUE
Montpellier, France Recruiting
Study contacts
- Study coordinator: Philippe Courtet, PhD
- Email: p-courtet@chu-montpellier.fr
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.