Respiratory health and wellbeing after pulmonary tuberculosis
Respiratory Health and Wellbeing Post Pulmonary Tuberculosis
Liverpool School of Tropical Medicine · NCT07178860
See if people treated for pulmonary TB in the UK have ongoing lung problems and reduced wellbeing after finishing treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Liverpool School of Tropical Medicine (other) |
| Locations | 1 site (Liverpool) |
| Trial ID | NCT07178860 on ClinicalTrials.gov |
What this trial studies
This observational study will recruit adults in the UK who had microbiologically confirmed pulmonary TB and completed treatment within the past 18 months. Participants will undergo lung function testing (spirometry), clinical history review, and standardized questionnaires about respiratory symptoms and quality of life, with additional tests or imaging if clinically indicated. The study will describe how common and how severe post-TB respiratory and wellbeing problems are in this population and compare findings with recent international post-TB care standards. Results will inform whether routine follow-up and specific interventions are needed for TB survivors in the UK.
Who should consider this trial
Good fit: Adults (18 or older) in the UK with microbiologically confirmed pulmonary TB who completed TB treatment within the last 18 months and can provide informed consent.
Not a fit: People with previously diagnosed, poorly controlled chronic lung disease, those unable to perform spirometry, or those with incomplete TB treatment records may not gain useful information from this study.
Why it matters
Potential benefit: If substantial post-TB problems are identified, the findings could support routine follow-up and targeted treatments to improve lung health and quality of life for TB survivors.
How similar studies have performed: Multiple studies from low- and middle-income countries have shown high rates of post-TB lung impairment and international guidance has been published, but comparable UK data are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\) Adults (over 18 years old) 2) Able to provide written informed consent 3) Previous diagnosis of microbiologically confirmed pulmonary TB 4) Completed TB treatment less than or equal to 18 months ago Exclusion Criteria: * 1\) Previously diagnosed clinically significant chronic lung disease that is not well-controlled (for example COPD on significant treatment, or poorly controlled asthma) 2) Unable to perform spirometry due to contraindications to spirometry 3) Under the age of 18 years at the time of recruitment (not the time of initial diagnosis) 4) Incomplete history of TB treatment
Where this trial is running
Liverpool
- Liverpool School of Tropical Medicine — Liverpool, United Kingdom (RECRUITING)
Study contacts
- Study coordinator: Rebecca Nightingale, PhD
- Email: rebecca.nightingale@lstmed.ac.uk
- Phone: 07702812183
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Tuberculosis, Post-TB, TB, Post-tuberculosis