Resistance training to improve blood sugar control in prediabetes
The Effect of Manipulating the Perception of Effort During Resistance Exercise Training on Glycemic Control and Psychological Responses in Individuals Living with Prediabetes: a Randomized-controlled Trial
NA · University of New Mexico · NCT06697756
This study tests whether different levels of resistance training can help people with prediabetes better control their blood sugar and feel more comfortable with exercise.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | University of New Mexico (other) |
| Drugs / interventions | rituximab |
| Locations | 1 site (Albuquerque, New Mexico) |
| Trial ID | NCT06697756 on ClinicalTrials.gov |
What this trial studies
This research investigates the effects of resistance exercise training at varying levels of effort on glycemic control and psychological responses in individuals with prediabetes. Prediabetes is a precursor to type 2 diabetes, characterized by elevated blood glucose levels that are not yet high enough to be classified as diabetes. The study aims to enhance exercise adherence by addressing psychological barriers and improving perceptions of exercise comfort while maintaining positive effects on glucose metabolism. Participants will engage in either high-effort or low-effort resistance training to assess the most effective approach for managing their condition.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 75 who have been diagnosed with prediabetes.
Not a fit: Patients with significant cognitive impairments, severe cardiovascular issues, or other serious health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide an effective non-pharmacological intervention to improve glycemic control in patients with prediabetes.
How similar studies have performed: Previous studies have shown that exercise interventions can be more effective than medication for improving glucose control in prediabetes, indicating a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age between 18 and 75 years; * presence of prediabetes (fasting glycemia between 100 and 125 mg/dL or glycated hemoglobin \[A1c\] between 5.7 and 6.4%). Exclusion Criteria: * Have a significant cognitive impairment, * Are non-ambulatory, * Have lower extremity amputation, * Have renal failure, * Have liver disease, * Have uncontrolled hypertension (\>160 mmHg systolic and/or \>100 mmHg diastolic), * Have unstable cardiovascular disease, * Have a history of severe cardiovascular problems, * Have decompensated heart failure, * Have uncontrolled arrhythmias, * Have severe pulmonary hypertension (mean pulmonary arterial pressure \>55 mm Hg), * Have severe and symptomatic aortic stenosis, * Have acute myocarditis, endocarditis, or pericarditis, * Have aortic dissection, * Have Marfan syndrome, * Have unrepaired aortic aneurysm, * Have proliferative diabetic retinopathy, * Have rapidly progressive terminal illness, * Are unable to perform resistance exercise to due preexisting musculoskeletal conditions (e.g., joint pain, chronic injury or tendinopathy), * Are under biguanide (metformin) treatment, but are taking for less than 3 months, * Have taken drugs known to increase the risk of tendon disorders (e.g., tendinopathy and tendon rupture) within the last 6 months. These drugs include, but may not be limited to: fluoroquinolones, glucocorticoids, aromatase inhibitors, anabolic steroids, antiretrovirals, isotretinoin, cephalexin, rituximab, sitagliptin, cephalosporins, azithromycin, and sulfonamides. * Are pregnant or trying to become pregnant during the study, * Are prisoners, * Are persons that require a legally authorized representative. Temporary exclusions include: * Being subjected to recent surgeries for which resistance training is not recommended, * Have symptomatic hernias, * Have acute illness, * Have recent fractures, or other injuries until resolved.
Where this trial is running
Albuquerque, New Mexico
- UNM Exercise Physiology Lab — Albuquerque, New Mexico, United States (RECRUITING)
Study contacts
- Study coordinator: Roberto Mota Alvidrez, MD
- Email: RMotaAlvidrez@salud.unm.edu
- Phone: 505-415-8005
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Prediabetes, resistance training, glycemic control