Resistance training load and blood pressure in postmenopausal women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Postmenopausal women aged 50–70 with normal-high or stage 1 hypertension who are physically inactive will perform resistance exercise sessions using low (50% 1‑RM) and high (80% 1‑RM) loads while keeping perceived effort high. Immediate post-exercise blood pressure and ambulatory blood pressure will be recorded, and researchers will measure autonomic activity, central (carotid) arterial compliance, and serum biomarkers of endothelial function to explore mechanisms. Participants will also report affective valence and enjoyment to assess acceptability of the two load approaches. Sessions require in-person visits to the Research Center on Aging in Sherbrooke with ambulatory monitoring between visits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* aged 50 to 70 years;
* absence of menstruation for 12 consecutive months;
* normal-high resting blood pressure (120 ≤ Systolic ≤ 139 mmHg and 80 ≤ Diastolic ≤ 89 mmHg) or stage 1 hypertension (140 ≤ Systolic ≤ 159 mmHg or 90 \< Diastolic ≤ 99 mmHg);
* physically inactive (\< 150 minutes of structured aerobic physical activity per week);
* and not engaging in regular resistance exercise (≥ 2 sessions per week) for more than 3 months during the year.

Exclusion Criteria:

* orthopedic limitations or other contraindications to resistance exercise;
* scheduled surgery during the study;
* unstable hypertension (≥ 160/100 mmHg);
* diagnosis of type 2 diabetes;
* cardiovascular event in the past 6 months or sequelae preventing exercise;
* and initiation of hormonal replacement therapy (\< 4 months) known to affect blood pressure.

Where it's running

• Research Center on Aging
  Sherbrooke, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Eléonor Riesco, Ph.D. — Université de Sherbrooke
• Study coordinator: Eléonor Riesco, Ph.D.
• Email: e.riesco@usherbrooke.ca
• Phone: 819-821-8000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.