Residual plaque risk during intensive cholesterol‑lowering in coronary heart disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Investigators will create a prospective cohort of patients with coronary heart disease who have undergone successful PCI and have non‑target lesions of 20–50% stenosis. Participants will undergo intravascular ultrasound (IVUS) imaging of non‑target lesions within the target vessel and serial measurement of lipid and inflammatory markers. Comprehensive clinical, laboratory, and imaging data will be collected with attention to medication adherence and relevant covariates. The goal is to link residual lipid and inflammatory risk profiles to plaque progression over follow‑up in a real‑world, well‑characterized population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with CAD and PCI was successfully performed.
* Presence of non-target lesions near the target lesion (more than 5mm proximal or distal), with stenosis of 20% to 50% and identifiable anatomical markers (e.g., branches, calcifications, stent edges).
* 18 to 75 years old.
* Written informed consent.

Exclusion Criteria:

* Known autoimmune diseases, or taking immunosuppressive drugs for a long time before onset.
* Known familial hypercholesterolemia.
* Critical conditions (e.g., cardiogenic shock, acute heart failure).
* Severe renal insufficiency (eGFR \< 30 mL /(min·1.73m2)), or severe hepatic insufficiency (ALT or AST≥3 times the upper limit of normal).
* Severe underlying diseases (such as end-stage malignancies), life expectancy \< 1 year.
* Allergic to lipid-lowering medications.
* Pregnant, or trying to become pregnant, and breastfeeding women.
* Other conditions deemed unsuitable for inclusion by the researcher.

Where it's running

• Shanghai Zhongshan Hospital
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Chunfeng Dai, M.D.
• Email: dai.chunfeng@zs-hospital.sh.cn
• Phone: 86-021-64041990

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.