Research on bronchiectasis in Chinese patients using genomics and endotyping

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The C-BRIDGE Study aims to characterize the phenotypes and endotypes of bronchiectasis in Chinese patients, addressing the lack of data specific to this population. By analyzing clinical, genomic, microbiological, and inflammatory factors, the study seeks to identify distinct patient subgroups and their responses to treatment. This observational study will involve patients during stable disease and exacerbations, with the goal of developing personalized medicine strategies based on the findings. The research will also explore specific conditions like allergic bronchopulmonary aspergillosis and primary ciliary dyskinesia to enhance understanding and management of bronchiectasis in China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A prior CT scan confirming bronchiectasis, accompanied by a compatible clinical syndrome including cough, sputum production, and/or recurrent respiratory tract infections.
* At the screening visit, participants must have been clinically stable for 4 weeks, defined as no antibiotic or corticosteroid treatment for a pulmonary exacerbation in the preceding 4 weeks.

Exclusion Criteria:

* Inability to provide informed consent
* Age under 18 years
* Patients with active tuberculosis
* Use of antibiotics or corticosteroids for a pulmonary exacerbation within the past 4 weeks

Where it's running

• Lin Liu
  Guiyang, Guizhou, China Recruiting
• Lei Song
  Changchun, Jilin, China Recruiting
• Qian Qi
  Jinan, Shangdong, China Recruiting
• He-feng Chen
  Shanghai, Shanghai Municipality, China Recruiting
• Zhou-fang Mei
  Shanghai, Shanghai Municipality, China Recruiting
• Jun She
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Yong-hua Gao, Ph.D. — Shanghai Pulmonary Hospital, Shanghai, China
• Study coordinator: Yong-hua Gao, Ph.D.
• Email: gaoyonghuahust@163.com
• Phone: +86 17321278520

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.