Reperfusion injury after mechanical thrombectomy for stroke
Hemodynamic Changes and Reperfusion Injury After Endovascular Stroke Treatment: Prospective Multicenter DYNASTROKE STUDY
This project tests whether bedside transcranial Duplex sonography together with MRI and blood markers can find patients at higher risk of brain bleeding or swelling after mechanical thrombectomy for large-vessel ischemic stroke.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical University of Graz Academic / other |
| Locations | 3 sites (Graz, Styria and 2 other locations) |
| Trial ID | NCT05273216 on ClinicalTrials.gov |
What this trial studies
This is a prospective, longitudinal multicenter study enrolling adults with anterior-circulation large vessel occlusion treated with mechanical thrombectomy at three Austrian stroke centers. Participants will undergo serial bedside transcranial Duplex sonography to detect increased flow velocity in the recanalized middle cerebral artery, perfusion MRI to confirm cerebral hyperperfusion, and blood sampling for biomarkers of blood-brain-barrier and neuroaxonal injury. The study will correlate these hemodynamic and biomarker findings with short-term outcomes including intracranial hemorrhage and vasogenic edema. The goal is to characterize reperfusion-related hemodynamic changes and identify bedside screening methods that predict post-thrombectomy complications.
Who should consider this trial
Good fit: Ideal candidates are adults (≥18 years) with anterior-circulation large-vessel occlusion who receive mechanical thrombectomy at one of the participating centers.
Not a fit: Patients with basilar artery occlusion, those treated outside the participating hospitals, or individuals under 18 are not eligible and are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the approach could enable early identification of patients at high risk of post-thrombectomy bleeding or edema so clinicians can intensify monitoring or adjust therapies to reduce complications.
How similar studies have performed: Small pilot studies have suggested bedside TCD can detect hyperperfusion associated with later hemorrhage, but multicenter prospective confirmation is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * stroke due to large vessel occlusion of the anterior cerebral circulation (internal carotid artery, middle cerebral artery) receiving mechanical thrombectomy. Exclusion Criteria: * basilar artery occlusion * age below 18 years
Where this trial is running
Graz, Styria and 2 other locations
- Medical Univerity of Graz, Department of Neurology — Graz, Styria, Austria (Recruiting)
- Medical University of Innsbruck, Department of Neurology — Innsbruck, Tyrol, Austria (Not_yet_recruiting)
- Paracelsus Medical University, Department of Neurology — Salzburg, Austria (Not_yet_recruiting)
Study contacts
- Study coordinator: Thomas Gattringer, MD, PhD
- Email: thomas.gattringer@medunigraz.at
- Phone: 004331638580231
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.