Reperfusion injury after mechanical thrombectomy for stroke
Official title: Hemodynamic Changes and Reperfusion Injury After Endovascular Stroke Treatment: Prospective Multicenter DYNASTROKE STUDY
Run by Medical University of Graz · NCT05273216 · Data updated 2026-11-12
This project tests whether bedside transcranial Duplex sonography together with MRI and blood markers can find patients at higher risk of brain bleeding or swelling after mechanical thrombectomy for large-vessel ischemic stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | Medical University of Graz Academic / other |
| Locations | 3 sites (Graz, Styria and 2 other locations) |
| Status | Recruiting |
| Started | October 1, 2021 |
| Main results expected | July 2026 |
| Study ends | July 2026 |
| Registry record updated | June 13, 2025 |
| Trial ID | NCT05273216 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (≥18 years) with anterior-circulation large-vessel occlusion who receive mechanical thrombectomy at one of the participating centers.
✕Probably not a fit
Patients with basilar artery occlusion, those treated outside the participating hospitals, or individuals under 18 are not eligible and are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, longitudinal multicenter study enrolling adults with anterior-circulation large vessel occlusion treated with mechanical thrombectomy at three Austrian stroke centers. Participants will undergo serial bedside transcranial Duplex sonography to detect increased flow velocity in the recanalized middle cerebral artery, perfusion MRI to confirm cerebral hyperperfusion, and blood sampling for biomarkers of blood-brain-barrier and neuroaxonal injury. The study will correlate these hemodynamic and biomarker findings with short-term outcomes including intracranial hemorrhage and vasogenic edema. The goal is to characterize reperfusion-related hemodynamic changes and identify bedside screening methods that predict post-thrombectomy complications.
Why it matters
Potential benefit: If successful, the approach could enable early identification of patients at high risk of post-thrombectomy bleeding or edema so clinicians can intensify monitoring or adjust therapies to reduce complications.
How similar studies have gone: Small pilot studies have suggested bedside TCD can detect hyperperfusion associated with later hemorrhage, but multicenter prospective confirmation is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * stroke due to large vessel occlusion of the anterior cerebral circulation (internal carotid artery, middle cerebral artery) receiving mechanical thrombectomy. Exclusion Criteria: * basilar artery occlusion * age below 18 years
Where it's running
-
Medical Univerity of Graz, Department of Neurology
Graz, Styria, Austria Recruiting -
Medical University of Innsbruck, Department of Neurology
Innsbruck, Tyrol, Austria Not yet recruiting -
Paracelsus Medical University, Department of Neurology
Salzburg, Austria Not yet recruiting
Study contacts
- Study coordinator: Thomas Gattringer, MD, PhD
- Email: thomas.gattringer@medunigraz.at
- Phone: 004331638580231
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.