Relationship between Periostin and ODI/Quality of Life in Lumbar Disc Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects blood samples to measure periostin and links those results to patient-reported outcomes like the Oswestry Disability Index (ODI) and EQ-5D in adults with lumbar disc disease. Participants are adults with MRI-confirmed lumbar disc herniation or spinal canal stenosis who can complete ODI and EQ-5D without assistance. The study does not involve an intervention beyond blood sampling and questionnaires, and it aims to explore potential biomarker associations with disease impact. Recruitment is limited to specific centers in Daegu, South Korea, with eligibility restricted by a comprehensive list of exclusion criteria to minimize confounding conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* lumbar disc herniation
* lumbar spinal canal stenosis
* patients who have MRI
* patients who can fill in the ODI and EQ5D without other's help

Exclusion Criteria:

* allergic disease
* allergic rhinitis
* asthma
* atopic dermatitis
* chronic sinusitis
* history of cancer
* fracture within 6 months
* severe osteoporosis
* knee osteoarthritis
* hip osteoarthrtis
* spinal surgery within 6 months
* myocardiac infarction
* heart failure
* liver cirrhosis
* chronic kidney disease
* rhematoid disease
* systemic lupus erythematosus
* ankylosing spondylitis
* Crohn's disease
* Ulcerative colitis
* systemic steroid user
* acute or chronic infection
* BMI \> 30
* uncontrolled hypertension
* uncontrolled diabetes
* recent history of vaccination

Where it's running

• Ji Hee
  Daegu, Daegu, South Korea Recruiting
• Hong Ji Hee
  Daegu, South Korea Recruiting

Study contacts

• Study coordinator: JIHEE Hong
• Email: swon13@daum.net
• Phone: 01046794343

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effect of NSAIDs on a blood marker (serum periostin) in people with back disc problems

  Researchers are testing whether taking NSAIDs influences serum periostin levels in patients with intervertebral disc problems and related back pain.

  Recruiting Keimyung University Dongsan Medical Center · Daegu · NCT07662668

• Autologous nucleus pulposus cell injection for degenerative lumbar disc disease.

  This trial will try a single injection of your own nucleus pulposus cells into a degenerated lumbar disc to see if it reduces pain and is safe for people who are having or need a discectomy.

  Recruiting Phase 1/2 ASTEROGENE Biomedical Co. Ltd. · Taipei · NCT07168603

• Evaluating the safety and performance of SpineVision's posterior fixation systems for spinal treatment

  This study is testing how safe and effective three different SpineVision devices are for treating people with spinal problems in their lower back.

  Recruiting at 3 sites Spinevision Sas · Bayonne and 2 other locations · NCT06342765

• Evaluating the Hexanium TLIF System for treating degenerative disc disease

  This study is testing a new system for back surgery to see if it safely helps people with degenerative disc disease feel less pain and improve their daily activities.

  Recruiting at 5 sites Spinevision Sas · Bruges and 5 other locations · NCT05997121

• Evaluating the safety and effectiveness of INFUSE Bone Graft for spinal fusion

  This study is testing how safe and effective the INFUSE Bone Graft is for spinal fusion surgery in patients in Korea over a year after their operation.

  Recruiting Medtronic Spinal and Biologics · Seoul · NCT05299762

• Creating a database of full body radiographs in healthy volunteers

  This study is trying to create a database of full body x-rays from healthy people to help doctors understand normal bone structure and improve treatment for spine issues.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT03076658

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.