Registry to track outcomes in patients with KRAS G12R altered advanced pancreatic cancer treated with MEK inhibitors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to collect and analyze patient data to evaluate the safety and efficacy of various MEK inhibitor-based combination therapies for individuals with KRAS G12R mutated advanced pancreatic ductal adenocarcinoma. It will involve a retrospective and prospective review of patient medical records, focusing on molecular profiling results and treatment responses. Key outcome measures will include tumor response, patient survival, and treatment toxicity, with the goal of assessing the feasibility of future clinical trials involving these therapies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years.
2. Diagnosis of advanced pancreatic ductal adenocarcinoma as determined by the treating physician or tumor board.
3. Tumor must have KRAS G12R mutation, as determined by a next generation sequencing (NGS) panel or circulating tumor DNA panel of choice of the treating physician.
4. Ability to understand a written informed consent document and the willingness to sign it.

Exclusion Criteria:

1. Age \<18 years.
2. Primary cancer diagnosis other than advanced pancreatic ductal adenocarcinoma
3. Tumor does not have a KRAS G12R mutation.

Where it's running

• Froedtert Hospital and the Medical College of Wisconsin
  Milwaukee, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Mandana Kamgar, MD, MPH — Medical College of Wisconsin
• Study coordinator: Mandana Kamgar, MD, MPH
• Email: mkamgar@mcw.edu
• Phone: 414-805-4600

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.