Registry for patients with non-obstructive coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the prevalence of ischemia in patients with non-obstructive coronary artery disease who are undergoing coronary angiography. It will stratify patients into different endotypes based on the presence of alternative causes of myocardial ischemia and implement tailored therapies. The study will evaluate the impact of these therapies on angina class, quality of life, and rates of cardiac hospitalization and coronary revascularization over a five-year follow-up period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical presentation of chronic ischemic heart dis- ease (IHD), requiring coronary angiography for the diagnosis;
* Absence of obstructive coronary artery disease (CAD) at coronary angiography;
* Age \> 18 years.
* Ability to provide a valid informed consent to the study procedure at the time of baseline evaluation;

Exclusion Criteria:

Clinical presentation of acute coronary syndrome (ACS) or cardiogenic shock;

* Presence of obstructive CAD with at least 1 significant coronary artery stenosis, defined as diameterstenosis \>50% and FFR ≤0.80 (or iFR/RFR ≤0.89);
* Previous coronary artery bypass grafting (CABG);
* Left ventricular systolic dysfunction, defined as ejection fraction (EF) \<40%;
* Severe valvular heart disease;
* Pregnant or breastfeeding women
* Known hypersensitivity or contraindication to any of the drugs used for coronary physiology testing (adenosine, nitrates, acetylcholine)
* Inability or unwillingness to provide a valid in- formed consent to the study procedure at the time of baseline evaluation.

Where it's running

• DPT of Advanced Biomedical Sciences
  Naples, Italy, Italy Recruiting

Study contacts

• Study coordinator: Luigi Di Serafino, MD, PhD
• Email: luigi.diserafino@unina.it
• Phone: 0039 347917374

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.