Registry for patients with advanced non-small cell lung cancer and specific genetic alterations
Official title: Disease Registry on Patients With Advanced NSCLC Harboring METex14 Skipping Alterations (MOMENT)
Run by EMD Serono · NCT05376891 · Data updated 2026-11-12
This study is collecting information from patients with advanced lung cancer who have a specific genetic change to see how they respond to different treatments over time.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 700 (estimated) |
| Sponsor | EMD Serono Industry-sponsored |
| Locations | 80 sites (Fort Lauderdale, Florida and 79 other locations) |
| Status | Recruiting |
| Started | October 4, 2022 |
| Main results expected | April 28, 2028 |
| Study ends | April 28, 2028 |
| Registry record updated | October 29, 2026 |
| Trial ID | NCT05376891 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this registry are individuals with advanced stage (stages IIIB-IV) NSCLC who have confirmed METex14 skipping alterations and are receiving systemic therapy.
✕Probably not a fit
Patients who are enrolled in other clinical trials may not benefit from this registry.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multi-national disease registry aims to collect high-quality, standardized data on patients with advanced non-small cell lung cancer (NSCLC) who have mesenchymal-epithelial transition exon 14 (METex14) skipping alterations. The registry will gather information on demographic and clinical characteristics, treatment patterns, and outcomes over time, following participants as they receive routine clinical care. By capturing this data, the registry seeks to provide insights into the evolving treatment landscape and effectiveness of systemic therapies for this specific patient population.
Why it matters
Potential benefit: If successful, this registry could enhance understanding of treatment outcomes and improve care strategies for patients with advanced NSCLC and METex14 alterations.
How similar studies have gone: Other disease registries have shown success in capturing valuable data and improving treatment understanding, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants who signed ICF * Participants with advanced stage (stages IIIB-IV) NSCLC (all histologies) and Confirmed METex14 skipping alterations (by valid assay) * Participants who are starting or are already being treated with systemic therapy Exclusion Criteria: * Participants who are enrolled in a clinical trial
Where it's running
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Holy Cross Health
Fort Lauderdale, Florida, United States Recruiting -
The Ohio State University Wexner Medical Center
Columbus, Ohio, United States Recruiting -
Klinikum Klagenfurt Am Woerthersee
Klagenfurt, Austria Recruiting -
Landeskrankenhaus Salzburg - Universitätsklinikum der PMU
Salzburg, Austria Recruiting -
Klinik Floridsdorf
Vienna, Austria Recruiting -
Jessa Ziekenhuis
Hasselt, Belgium Recruiting
Show 44 more locations
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AZ Delta
Roeselare, Belgium Recruiting -
AZ Nikolaas
Sint-Niklaas, Belgium Recruiting -
Cliniques UCL de Mont-Godinne (7077)
Yvoir, Belgium Recruiting -
Ottawa Hospital General Campus
Ottawa, Canada Recruiting -
Centre Intégré de Cancérologie du CHU de Québec
Québec, Canada Recruiting -
Princess Margaret Cancer Centre
Toronto, Canada Recruiting -
British Columbia Cancer Agency (6864)
Vancouver, Canada Recruiting -
FN Olomouc
Olomouc, Czechia Recruiting -
University Hospital Na Bulovce
Prague, Czechia Recruiting -
Centre Hospitalier de Cholet
Cholet, France Recruiting -
CHRU Lille
Lille, France Recruiting -
Hôpital du Scorff
Lorient, France Recruiting -
Centre Leon Berard
Lyon, France Recruiting -
Groupe Hospitalier Paris Saint Joseph
Paris, France Recruiting -
Hospital Tenon & University Paris 6
Paris, France Recruiting -
Institut Curie - Centre de Lutte Contre le Cancer (CLCC)
Paris, France Recruiting -
CHU de Pontchaillou
Rennes, France Recruiting -
CHU de Toulouse Hopital Larrey
Toulouse, France Recruiting -
Klinikum Chemnitz GmbH
Chemnitz, Germany Recruiting -
KKH Grosshansdorf GmbH
Großhansdorf, Germany Recruiting -
Thoraxklinik-Heidelberg gGmbH
Heidelberg, Germany Recruiting -
Klinik Löwenstein GmbH
Löwenstein, Germany Recruiting -
Haemek Medical Center
Afula, Israel Recruiting -
Bnei-Zion Medical Center
Haifa, Israel Recruiting -
Carmel Medical Center
Haifa, Israel Recruiting -
Rambam Medical Center - PPDS
Haifa, Israel Recruiting -
Shaare Zedek Medical Center
Jerusalem, Israel Recruiting -
Rabin Medical Center Oncology Beilinson Campus
Petah Tikva, Israel Recruiting -
Chaim Sheba Medical Center
Ramat Gan, Israel Recruiting -
Tel Aviv Sourasky Medical Center
Tel Aviv, Israel Recruiting -
Humanitas Istituto Clinico Catanese
Misterbianco, Sicily, Italy Recruiting -
Istituto Europeo di Oncologia
Milan, Italy Recruiting -
Istituto Nazionale Dei Tumori
Milan, Italy Recruiting -
Azienda Ospedaliero Universitaria di Modena
Modena, Italy Recruiting -
Azienda Ospedaliera Dei Colli - Ospedale Monaldi
Naples, Italy Recruiting -
AOU dell'Università degli Studi della Campania Luigi Vanvitelli
Naples, Italy Recruiting -
I.F.O. Istituto Nazionale Tumori Regina Elena IRCCS
Rome, Italy Recruiting -
Azienda Sanitaria Ospedaliera S Luigi Gonzaga
Torino, Italy Recruiting -
Ospedale di Circolo
Varese, Italy Recruiting -
Erasmus MC
Rotterdam, South Holland, Netherlands Recruiting -
VU Medisch Centrum
Amsterdam, Netherlands Recruiting -
Universitair Medisch Centrum Groningen - Department of Medical Oncology
Groningen, Netherlands Recruiting -
Leiden University Medical Center
Leiden, Netherlands Recruiting -
Z.O.L. Campus Sint Jan (975)
Roosendaal, Netherlands Recruiting
+30 more sites. See ClinicalTrials.gov for the full list.
Study contacts
- Study coordinator: US Medical Information
- Email: eMediUSA@emdserono.com
- Phone: 888-275-7376
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.