Clinical trial Recruiting at 73 sites Observational

Registry for patients with advanced non-small cell lung cancer and specific genetic alterations

Official title: Disease Registry on Patients With Advanced NSCLC Harboring METex14 Skipping Alterations (MOMENT)

Run by EMD Serono · NCT05376891 · Data updated 2026-11-12

This study is collecting information from patients with advanced lung cancer who have a specific genetic change to see how they respond to different treatments over time.

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Quick facts

Study typeObservational
SexAll
Enrollment700 (estimated)
SponsorEMD Serono
Industry-sponsored
Locations80 sites (Fort Lauderdale, Florida and 79 other locations)
StatusRecruiting
StartedOctober 4, 2022
Main results expectedApril 28, 2028
Study endsApril 28, 2028
Registry record updatedOctober 29, 2026
Trial IDNCT05376891 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this registry are individuals with advanced stage (stages IIIB-IV) NSCLC who have confirmed METex14 skipping alterations and are receiving systemic therapy.

Probably not a fit

Patients who are enrolled in other clinical trials may not benefit from this registry.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multi-national disease registry aims to collect high-quality, standardized data on patients with advanced non-small cell lung cancer (NSCLC) who have mesenchymal-epithelial transition exon 14 (METex14) skipping alterations. The registry will gather information on demographic and clinical characteristics, treatment patterns, and outcomes over time, following participants as they receive routine clinical care. By capturing this data, the registry seeks to provide insights into the evolving treatment landscape and effectiveness of systemic therapies for this specific patient population.

Why it matters

Potential benefit: If successful, this registry could enhance understanding of treatment outcomes and improve care strategies for patients with advanced NSCLC and METex14 alterations.

How similar studies have gone: Other disease registries have shown success in capturing valuable data and improving treatment understanding, making this approach both relevant and potentially impactful.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participants who signed ICF
* Participants with advanced stage (stages IIIB-IV) NSCLC (all histologies) and Confirmed METex14 skipping alterations (by valid assay)
* Participants who are starting or are already being treated with systemic therapy

Exclusion Criteria:

* Participants who are enrolled in a clinical trial

Where it's running

  • Holy Cross Health
    Fort Lauderdale, Florida, United States
    Recruiting
  • The Ohio State University Wexner Medical Center
    Columbus, Ohio, United States
    Recruiting
  • Klinikum Klagenfurt Am Woerthersee
    Klagenfurt, Austria
    Recruiting
  • Landeskrankenhaus Salzburg - Universitätsklinikum der PMU
    Salzburg, Austria
    Recruiting
  • Klinik Floridsdorf
    Vienna, Austria
    Recruiting
  • Jessa Ziekenhuis
    Hasselt, Belgium
    Recruiting
Show 44 more locations
  • AZ Delta
    Roeselare, Belgium
    Recruiting
  • AZ Nikolaas
    Sint-Niklaas, Belgium
    Recruiting
  • Cliniques UCL de Mont-Godinne (7077)
    Yvoir, Belgium
    Recruiting
  • Ottawa Hospital General Campus
    Ottawa, Canada
    Recruiting
  • Centre Intégré de Cancérologie du CHU de Québec
    Québec, Canada
    Recruiting
  • Princess Margaret Cancer Centre
    Toronto, Canada
    Recruiting
  • British Columbia Cancer Agency (6864)
    Vancouver, Canada
    Recruiting
  • FN Olomouc
    Olomouc, Czechia
    Recruiting
  • University Hospital Na Bulovce
    Prague, Czechia
    Recruiting
  • Centre Hospitalier de Cholet
    Cholet, France
    Recruiting
  • CHRU Lille
    Lille, France
    Recruiting
  • Hôpital du Scorff
    Lorient, France
    Recruiting
  • Centre Leon Berard
    Lyon, France
    Recruiting
  • Groupe Hospitalier Paris Saint Joseph
    Paris, France
    Recruiting
  • Hospital Tenon & University Paris 6
    Paris, France
    Recruiting
  • Institut Curie - Centre de Lutte Contre le Cancer (CLCC)
    Paris, France
    Recruiting
  • CHU de Pontchaillou
    Rennes, France
    Recruiting
  • CHU de Toulouse Hopital Larrey
    Toulouse, France
    Recruiting
  • Klinikum Chemnitz GmbH
    Chemnitz, Germany
    Recruiting
  • KKH Grosshansdorf GmbH
    Großhansdorf, Germany
    Recruiting
  • Thoraxklinik-Heidelberg gGmbH
    Heidelberg, Germany
    Recruiting
  • Klinik Löwenstein GmbH
    Löwenstein, Germany
    Recruiting
  • Haemek Medical Center
    Afula, Israel
    Recruiting
  • Bnei-Zion Medical Center
    Haifa, Israel
    Recruiting
  • Carmel Medical Center
    Haifa, Israel
    Recruiting
  • Rambam Medical Center - PPDS
    Haifa, Israel
    Recruiting
  • Shaare Zedek Medical Center
    Jerusalem, Israel
    Recruiting
  • Rabin Medical Center Oncology Beilinson Campus
    Petah Tikva, Israel
    Recruiting
  • Chaim Sheba Medical Center
    Ramat Gan, Israel
    Recruiting
  • Tel Aviv Sourasky Medical Center
    Tel Aviv, Israel
    Recruiting
  • Humanitas Istituto Clinico Catanese
    Misterbianco, Sicily, Italy
    Recruiting
  • Istituto Europeo di Oncologia
    Milan, Italy
    Recruiting
  • Istituto Nazionale Dei Tumori
    Milan, Italy
    Recruiting
  • Azienda Ospedaliero Universitaria di Modena
    Modena, Italy
    Recruiting
  • Azienda Ospedaliera Dei Colli - Ospedale Monaldi
    Naples, Italy
    Recruiting
  • AOU dell'Università degli Studi della Campania Luigi Vanvitelli
    Naples, Italy
    Recruiting
  • I.F.O. Istituto Nazionale Tumori Regina Elena IRCCS
    Rome, Italy
    Recruiting
  • Azienda Sanitaria Ospedaliera S Luigi Gonzaga
    Torino, Italy
    Recruiting
  • Ospedale di Circolo
    Varese, Italy
    Recruiting
  • Erasmus MC
    Rotterdam, South Holland, Netherlands
    Recruiting
  • VU Medisch Centrum
    Amsterdam, Netherlands
    Recruiting
  • Universitair Medisch Centrum Groningen - Department of Medical Oncology
    Groningen, Netherlands
    Recruiting
  • Leiden University Medical Center
    Leiden, Netherlands
    Recruiting
  • Z.O.L. Campus Sint Jan (975)
    Roosendaal, Netherlands
    Recruiting

+30 more sites. See ClinicalTrials.gov for the full list.

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.