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Registry for patient experiences with carpal tunnel release procedures

Registry of the Patient Experience for Carpal Tunnel Release (MISSION)

Observational Sonex Health, Inc. · NCT06071468

This study is collecting experiences from people with carpal tunnel syndrome who are having different types of surgery to see how well they do over two years after the procedures.

Quick facts

Study typeObservational
Enrollment2000 (estimated)
Ages18 Years and up
SexAll
SponsorSonex Health, Inc. Industry-sponsored
Locations37 sites (Foley, Alabama and 36 other locations)
Trial IDNCT06071468 on ClinicalTrials.gov

What this trial studies

This multicenter observational study aims to collect extensive real-world data on patients diagnosed with carpal tunnel syndrome (CTS) who are undergoing various forms of carpal tunnel release, including ultrasound-guided, endoscopic, and open techniques. Participants will be monitored over a 24-month period, providing insights into their experiences and outcomes following the procedures. The study will include patients who have previously tried nonsurgical treatments without success and will utilize both clinical assessments and patient-reported outcomes to evaluate effectiveness.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with a clinical diagnosis of unilateral or bilateral carpal tunnel syndrome who have not responded to nonsurgical treatments.

Not a fit: Patients who have not been diagnosed with carpal tunnel syndrome or those who have not attempted nonsurgical treatments may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance understanding of patient experiences and outcomes, leading to improved treatment strategies for carpal tunnel syndrome.

How similar studies have performed: Other studies have successfully utilized similar observational approaches to gather patient data, indicating potential for valuable insights in this area.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria 1. ≥18 years of age 2. Clinical diagnosis of unilateral or bilateral CTS 3. A clinical decision has been made to perform CTR on one or both hands 4. CTS-6 score ≥12 in the target hand(s)\* 5. Confirmatory diagnostic testing in the target hand(s)\*:

1. CTR-US: Confirmatory diagnostic testing with ultrasound (median nerve cross-sectional area ≥10 mm2 in the proximal carpal tunnel region)
2. ECTR or OCTR: Confirmatory electrodiagnostic testing 6. Prior failure of one or more nonsurgical treatment options (e.g., physical activity modification, bracing, splinting, corticosteroid injection) in the target hand(s) 7. Patient agrees to complete follow-up questionnaires over a 24-month period 8. Patient has a valid smart phone number and/or email address to receive and answer follow-up questionnaires

Note: An asterisk (\*) denotes that this criterion must be applied to the target hand for unilateral CTR procedures, or to both hands for simultaneous bilateral CTR procedures.

Exclusion Criteria:

1. Patient meets any of the contraindications per Instruction For Use (IFU)
2. Patient has other medical, social, or psychological conditions that, in the opinion of the investigator, preclude them from completing all registry requirements.

Where this trial is running

Foley, Alabama and 36 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Carpal Tunnel SyndromeCTSUltrasound Guided Carpal Tunnel ReleaseCTR-USECTROCTR
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.