Registry for invasive Candida infections
ECMM Candida Registry - CandiReg
This study is collecting information about invasive Candida infections to help doctors understand how often they happen, who is most at risk, and how well different treatments work.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Sex | All |
| Sponsor | University of Cologne Academic / other |
| Locations | 1 site (Cologne, North Rhine-Westphalia) |
| Trial ID | NCT03450005 on ClinicalTrials.gov |
What this trial studies
The ECMM Candida Registry (CandiReg) aims to enhance understanding of invasive Candida infections by documenting their global incidence, clinical patterns, and antifungal resistance. This observational study will collect data on patient demographics, risk factors, and treatment regimens to inform future guidelines and improve patient outcomes. It will also establish a collection of isolates for molecular characterization and resistance gene evaluation. The registry will serve as a platform for future studies and outbreak responses.
Who should consider this trial
Good fit: Ideal candidates include individuals with confirmed invasive Candida infections, such as hepatosplenic candidiasis or other disseminated infections.
Not a fit: Patients with non-invasive Candida infections, such as superficial skin infections or candiduria without dissemination, will not benefit from this study.
Why it matters
Potential benefit: If successful, this registry could lead to improved diagnosis, treatment, and management of invasive Candida infections, ultimately reducing mortality rates.
How similar studies have performed: While there have been studies on Candida infections, this registry approach is relatively novel and aims to fill significant gaps in current knowledge.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cultural, histopathological, antigen or DNA evidence of invasive fungal infection with Candida species. * Hepatosplenic candidiasis with signs of disseminated Candida infection without culture, histological or microscopic evidence * Case control Matching procedure for controls: In part, controls will be included at the same hospitals that include cases (i.e. each one control per case, both in the same hospital). Controls will be matched by demographics, underlying diseases and risk factors as well as duration of hospitalization Exclusion Criteria: \- Colonization or other non-invasive infection, including superficial skin infections, candiduria without dissemination or Candida spp. in stool.
Where this trial is running
Cologne, North Rhine-Westphalia
- University Hospital Cologne — Cologne, North Rhine-Westphalia, Germany (Recruiting)
Study contacts
- Study coordinator: Oliver Cornely, MD
- Email: oliver.cornely@uk-koeln.de
- Phone: +49 221 478
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.