Registry for imaging measures of respiratory health

Imaging Measures of Respiratory Health Registry

This study is collecting information on lung health using advanced MRI scans to see how well lungs work in both healthy people and those with breathing problems.

Quick facts

• Study type: Observational
• Enrollment: 1000 (estimated)
• Ages: 0 Years to 99 Years
• Sex: All
• Sponsor: University of British Columbia (Academic / other)
• Locations: 2 sites (Vancouver, British Columbia and 1 other locations)
• Trial ID: NCT05102825 on ClinicalTrials.gov

What this trial studies

This observational cohort registry collects data on pulmonary structure and function in both healthy individuals and those with respiratory diseases using advanced MRI techniques. The study employs 1H-MRI and hyperpolarized 129Xe-MRI to assess regional ventilation, pulmonary microarchitecture, and gas exchange. Additionally, it aims to develop novel image analysis techniques to enhance understanding of respiratory health. Data collected will include demographic, clinical, and pulmonary function testing information.

Who should consider this trial

Good fit: Ideal candidates include individuals aged 0-99 years with physician-diagnosed lung disease or healthy individuals willing to participate.

Not a fit: Patients requiring supplementary oxygen or those with claustrophobia may not benefit from this study.

Why it matters

Potential benefit: If successful, this registry could lead to improved diagnostic and treatment strategies for respiratory diseases.

How similar studies have performed: Other studies utilizing advanced MRI techniques for respiratory health have shown promise, indicating potential for success in this approach.

Eligibility criteria

Respiratory Disease

Inclusion Criteria:

1. Physician-diagnosed lung disease - based on a diagnosis made by a treating staff physician and confirmed by the principal investigator.
2. Age 0-99 years.
3. Informed consent by participant, parent, or legal guardian
4. In the opinion of the Investigator, the participant will likely be able to perform maneuvers to obtain technically acceptable pulmonary XeMRI images.

Exclusion Criteria:

1. Physical findings at screening that, in the opinion of the Investigator, would compromise the safety of the participant or the quality of the research data.
2. Requirement of supplementary oxygen to maintain an oxygen saturation above 95%.
3. Failed MRI screening form.
4. History of claustrophobia.
5. Known current pregnancy or lactation.

Healthy

Inclusion Criteria:

1. Age 0-99 years
2. Informed consent by participant, parent, or legal guardian
3. In the opinion of the Investigator, the participant will likely be able to perform maneuvers to obtain technically acceptable pulmonary MRI images.

Exclusion Criteria

1. Physician-diagnosed lung disease.
2. Failed MRI screening form.
3. History of claustrophobia.
4. Physical findings at screening that, in the opinion of the Investigator, would compromise the safety of the participant or the quality of the research data.
5. Known current pregnancy or lactation.

Where this trial is running

Vancouver, British Columbia and 1 other locations

• British Columbia Children's Hospital — Vancouver, British Columbia, Canada (Recruiting)
• St. Paul's Hospital — Vancouver, British Columbia, Canada (Recruiting)

Study contacts

• Principal investigator: Jonathan Rayment, MDCM, MSc — University of British Columbia
• Study coordinator: Rodrigo Sandoval, MSc

Conditions Respiratory Disease; Healthy