Registry for imaging measures of respiratory health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort registry collects data on pulmonary structure and function in both healthy individuals and those with respiratory diseases using advanced MRI techniques. The study employs 1H-MRI and hyperpolarized 129Xe-MRI to assess regional ventilation, pulmonary microarchitecture, and gas exchange. Additionally, it aims to develop novel image analysis techniques to enhance understanding of respiratory health. Data collected will include demographic, clinical, and pulmonary function testing information.

Why it matters

Who can join: the full rules

Respiratory Disease

Inclusion Criteria:

1. Physician-diagnosed lung disease - based on a diagnosis made by a treating staff physician and confirmed by the principal investigator.
2. Age 0-99 years.
3. Informed consent by participant, parent, or legal guardian
4. In the opinion of the Investigator, the participant will likely be able to perform maneuvers to obtain technically acceptable pulmonary XeMRI images.

Exclusion Criteria:

1. Physical findings at screening that, in the opinion of the Investigator, would compromise the safety of the participant or the quality of the research data.
2. Requirement of supplementary oxygen to maintain an oxygen saturation above 95%.
3. Failed MRI screening form.
4. History of claustrophobia.
5. Known current pregnancy or lactation.

Healthy

Inclusion Criteria:

1. Age 0-99 years
2. Informed consent by participant, parent, or legal guardian
3. In the opinion of the Investigator, the participant will likely be able to perform maneuvers to obtain technically acceptable pulmonary MRI images.

Exclusion Criteria

1. Physician-diagnosed lung disease.
2. Failed MRI screening form.
3. History of claustrophobia.
4. Physical findings at screening that, in the opinion of the Investigator, would compromise the safety of the participant or the quality of the research data.
5. Known current pregnancy or lactation.

Where it's running

• British Columbia Children's Hospital
  Vancouver, British Columbia, Canada Recruiting
• St. Paul's Hospital
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Principal investigator: Jonathan Rayment, MDCM, MSc — University of British Columbia
• Study coordinator: Rodrigo Sandoval, MSc
• Email: Rodrigo.Sandoval@bcchr.ca
• Phone: 6048752345

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.