Registry for Automated Mechanical Ventilation in Adults
Run by Hamilton Medical AG · NCT06655805 · Data updated 2026-11-12
This study tests a new automated breathing support system to see if it can help critically ill patients in the ICU breathe better and reduce lung damage.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Hamilton Medical AG Industry-sponsored |
| Locations | 4 sites (Sankt Gallen, Canton of St. Gallen and 3 other locations) |
| Status | Recruiting |
| Started | September 23, 2024 |
| Main results expected | June 30, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | January 16, 2026 |
| Trial ID | NCT06655805 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who require respiratory support such as high-flow nasal oxygen, non-invasive ventilation, or invasive mechanical ventilation during their ICU stay.
✕Probably not a fit
Patients who are expected to be weaned from respiratory support within 2 hours or are moribund with an expected death within 2 hours may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the safety and performance of Hamilton Medical AG's automated mechanical ventilation software in critically ill patients requiring respiratory support in the intensive care unit. It focuses on collecting real-world evidence to assess how advanced ventilation modes can optimize patient outcomes and minimize lung injury. The study will involve patients who need non-invasive ventilation, invasive mechanical ventilation, or high-flow nasal oxygen during their ICU stay.
Why it matters
Potential benefit: If successful, this study could enhance the safety and effectiveness of mechanical ventilation for critically ill patients.
How similar studies have gone: Other studies have shown promise in using advanced mechanical ventilation technologies, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Age ≥ 18 years. Any patient in need of HFNO, NIV and IMV at some time during its ICU stay. Exclusion Criteria: Expected to be weaned from HFNO, NIV within 2 hours. Expected to be weaned and extubated from IMV without subsequent need of HFNO or NIV support within 2 hours. Expected to be transferred to another non-participating ICU within 2 hours. Moribund subject: death expected within 2 hours.
Where it's running
-
HOCH Health Ostschweiz, Clinics for Intensive Care Medicine, Surgical ICU
Sankt Gallen, Canton of St. Gallen, Switzerland Recruiting -
Kantonsspital Chur
Chur, Kanton Graubünden, Switzerland Recruiting -
HOCH Health Ostschweiz, Clinics for Intensive Care Medicine, Medical ICU
Sankt Gallen, St.Gallen, Switzerland Recruiting -
Kantonsspital Winterthur, Zentrum für Intensivmedizin
Winterthur, Switzerland Recruiting
Study contacts
- Principal investigator: Francesca Porta, MD — Kantonsspital Chur, Chur, Switerzland 7000
- Study coordinator: Marco V Maggiorini, MD
- Email: mmaggiorini@hamilton-medical.com
- Phone: +41586101514
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Dynamic, non-invasive monitoring of breathing effort to guide weaning from mechanical ventilation
This observational study tests whether daily non-invasive measurements of a patient’s breathing effort can predict when it’s safe to take them off invasive ventilation.
-
Early Non-Invasive Ventilation in ALS
This study tests whether starting non-invasive ventilation earlier in adults with ALS can help improve breathing and quality of life.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.