Reducing vancomycin use in newborn intensive care

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, cluster-randomized implementation trial in Level III NICUs affiliated with Kaiser Permanente Northern California or the Children’s Hospital of Philadelphia network. Participating sites are randomized to receive external facilitation or usual implementation support, with interventions aimed at hospital staff such as identifying local champions, educational outreach, unit-level audit and feedback, and a clinical decision support tool. The primary outcome is center-level fidelity to the core components of vancomycin-reducing practices, with the goal of changing prescribing behavior across the unit. Data will be collected at the site level to compare adoption and sustainment between arms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Level III NICU
* Affiliated with Kaiser Permanente Northern California (KPNC) or Children's Hospital of Philadelphia Newborn Care Network (CNBCN)
* Recruited by study team

Exclusion Criteria:

* Site not recruited for the study

Where it's running

• Kaiser Permanente Modesto Medical Center
  Modesto, California, United States Recruiting
• Kaiser Permanente East Bay - Oakland Medical Center
  Oakland, California, United States Recruiting
• Kaiser Permanente Roseville Medical Center
  Roseville, California, United States Recruiting
• Kaiser Permanente San Francisco Medical Center
  San Francisco, California, United States Recruiting
• Kaiser Permanente San Leandro Medical Center
  San Leandro, California, United States Recruiting
• Kaiser Permanente Santa Clara Medical Center
  Santa Clara, California, United States Recruiting

Study contacts

• Principal investigator: Sagori Mukhopadhyay, MD, MMSc — Children's Hospital of Philadelphia
• Study coordinator: Kayla Gilpin
• Email: kayla.gilpin@pennmedicine.upenn.edu
• Phone: 215-573-3976

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.