Reducing unnecessary MRSA treatment in pneumonia patients using nasal screening

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of a nasal PCR-assay for MRSA in guiding the rapid de-escalation of anti-MRSA therapy in hospitalized patients with pneumonia. By utilizing this diagnostic tool, the study seeks to minimize the duration of unnecessary antibiotic treatment, which can lead to adverse effects and increased healthcare costs. The primary focus is on patients diagnosed with community-acquired, hospital-acquired, or ventilator-associated pneumonia, and the study will measure outcomes such as in-hospital mortality, length of stay, and incidence of adverse drug events. Enrollment occurs within 48 hours of starting empirical anti-MRSA therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects 18 years or older.
* Patients hospitalized at the Azienda Consorziale Policlinico di Bari;
* Clinical diagnosis of CAP/HAP/VAP;
* Commitment by the prescribing physician to set an anti-MRSA antibiotic therapy in empirical
* Enrollement within 48h from the beginning of the empirical anti-MRSA therapy.

Exclusion Criteria:

* Febrile neutropenia or severe immunodeficiency;
* Chronic airway infection (eg cystic fibrosis);
* Suspect of extrapulmonary infection by MRSA
* Refusal by the patient or legal guardian;
* Refusal by the physician in charge of the patient to perform antibiotic de-escalation based on the result of the nasal swab;
* Enrollment after 48 hours from the beginning of the empirical anti-MRSA therapy.

Where it's running

• Università di Bari "Aldo Moro"
  Bari, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.