Reducing unnecessary antibiotic use for pneumonia patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to minimize the use of broad-spectrum antibiotics in patients with community-acquired pneumonia (CAP) by implementing rapid diagnostic testing and pharmacist-led de-escalation strategies. It will be conducted as a pragmatic, multicenter, cluster randomized controlled trial over three years, comparing four different approaches: rapid diagnostic testing, pharmacist-led de-escalation, a combination of both, and usual care. The goal is to enhance the accuracy of pathogen detection and improve antibiotic stewardship practices following negative culture results.

Why it matters

Who can join: the full rules

Inclusion Criteria for patient's records:

1. Men or women greater than or equal to 18 years of age
2. Admitted to a participating (i.e. enrolled and randomized) hospital
3. Admitting diagnosis of pneumonia

Exclusion Criteria:

1. Admission to intensive care unit within 24 hours of hospital admission
2. Comfort care measures only
3. Cystic fibrosis
4. Discharged from an acute care hospital in the past week
5. Patients not eligible for empiric therapy due to a known pathogen (any positive blood or respiratory cultures in the 72 hours prior to admission)

Where it's running

• Indian River Hospital
  Vero Beach, Florida, United States Recruiting
• Weston Hospital/Cleveland Clinic Florida
  Weston, Florida, United States Recruiting
• Akron General Hospital
  Akron, Ohio, United States Recruiting
• Avon Hospital
  Avon, Ohio, United States Recruiting
• Lutheran Hospital
  Cleveland, Ohio, United States Recruiting
• Cleveland Clinic Main Campus
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Michael Rothberg, M.D. — The Cleveland Clinic
• Study coordinator: Michael Rothberg, M.D.
• Email: ROTHBEM@ccf.org
• Phone: 216-445-0719

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.