Reducing sore throat after thyroid or parathyroid surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, single-center trial will enroll 764 adults undergoing elective open thyroid or parathyroid surgery with intraoperative neuromonitoring and randomly assign them to receive an endotracheal tube coated with either hydrocortisone 1% ointment or lidocaine 0.05% with chlorhexidine. The coated tube will be used during standard anesthesia and surgery, and patients will be monitored per routine clinical care. Outcomes — throat pain, hoarseness, and cough — will be measured on awakening, at 24 hours, and at 3 days postoperatively. Results aim to inform simple, low-cost measures to improve early postoperative comfort after these procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients scheduled for elective open surgery on the thyroid/parathyroid glands with intraoperative neuromonitoring.
* Age ≥18 years.
* Willing and able to provide voluntary informed consent for participation in the study.

Exclusion Criteria:

* Pregnancy (for women of childbearing potential).
* Known allergy to hydrocortisone or lidocaine.
* Refusal to participate in the study.

Where it's running

• Saint Petersburg State University Hospital
  Saint Petersburg, Russia Recruiting

Study contacts

• Principal investigator: Sergey M. Efremov, MD, PhD — Saint Petersburg State University Hospital
• Study coordinator: Sergey M. Efremov, D. Med. Sc.
• Email: efremovsergm@gmail.com
• Phone: +79137946090

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.