Reducing sedentary behavior to enhance exercise benefits
Preventing Exercise Resistance With Sedentary Interruptions
This study is testing if switching between sitting and standing while working can help office workers at risk for chronic diseases get more benefits from exercise.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 30 Years to 65 Years |
| Sex | All |
| Sponsor | Hasselt University Academic / other |
| Locations | 1 site (Diepenbeek, Limburg) |
| Trial ID | NCT06277713 on ClinicalTrials.gov |
What this trial studies
This randomized cross-over trial investigates how alternating between sitting and standing during work hours affects the metabolic response to exercise in office workers at risk for chronic diseases. Participants will undergo three intervention periods, each lasting two days, where they will engage in a supervised exercise session and have their postprandial metabolism assessed after a standardized meal. The study aims to determine if reducing sedentary time can enhance the lipid-lowering effects of exercise, addressing the issue of sitting-induced exercise resistance.
Who should consider this trial
Good fit: Ideal candidates are office workers aged 30 to 65 who are sedentary for more than 9 hours a day and have an increased risk for lipid metabolism disorders.
Not a fit: Patients with medical conditions that prevent physical activity or those with existing cardiometabolic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for enhancing the health benefits of exercise in sedentary individuals.
How similar studies have performed: While some studies have explored the effects of sedentary behavior on health, this specific approach of combining standing interruptions with exercise is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * between 30 and 65 years old, * primarily work in an office environment for at least 0.75 full time equivalents, * sedentary (on average \>9h of sedentary time per day, assessed objectively), * at an increased risk for disturbances in lipid profile (assessed with fingerstick (Analox®) total cholesterol \>200 mg/dL or fingerstick triglycerides \>150 mg/dL), * written informed consent to participate in the study. Exclusion Criteria: * medical conditions precluding physical activity (PA) participation, * abusive alcohol intake (\>20 units/week), * pregnant or intention to become pregnant, * change in dietary habits or weight loss (\>2kg) in the last month before the study, * a diagnosis of cardiometabolic diseases such as diabetes mellitus or cardiovascular diseases.
Where this trial is running
Diepenbeek, Limburg
- Hasselt University — Diepenbeek, Limburg, Belgium (Recruiting)
Study contacts
- Principal investigator: Bert Op 't Eijnde, Prof. dr. — Hasselt University
- Study coordinator: Bert Op 't Eijnde, Prof. dr.
- Email: bert.opteijnde@uhasselt.be
- Phone: +3211292121
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.