Reducing disgust in contamination-based OCD using conditioning and brain stimulation
Disgust Reduction Through Evaluative Conditioning and tDCS in Patients With Contamination-Based OCD
NA · Ferdowsi University of Mashhad · NCT05907369
This study is testing a new way to help people with contamination-based OCD by using special training and brain stimulation to reduce their feelings of disgust.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 55 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | Ferdowsi University of Mashhad (other) |
| Locations | 1 site (Mashhad, Khorassan Razavi) |
| Trial ID | NCT05907369 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to address contamination-based obsessive-compulsive disorder (OCD) by utilizing evaluative conditioning (EC) to reduce disgust responses associated with contamination stimuli. Participants will undergo training that pairs disgust-eliciting images with positive images to alter their emotional responses. Additionally, transcranial direct current stimulation (tDCS) will be applied to enhance the effects of the EC training. The study seeks to improve treatment outcomes for individuals who have not responded adequately to traditional therapies.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with contamination-based OCD who have stable medication and can engage in computerized tasks.
Not a fit: Patients with severe physical illnesses, other severe mental disorders, or those with a history of epilepsy or neurological disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a novel and effective treatment option for patients suffering from contamination-based OCD.
How similar studies have performed: While the approach of using evaluative conditioning in OCD is promising, it is still relatively novel and has not been extensively tested in this specific context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The Diagnostic criteria of OCD in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5-TR) with the symptoms of contamination subtype * Able to read, write and do computerized tasks * Stable medication for at least the last three months * Filling out the written consent Exclusion Criteria: * Severe physical illness * Severe other mental disorders * Alcohol and drug dependence * A history of epilepsy or seizure * Have metal or electronic implants in the head or use a cardiac pacemaker * History of head trauma or neurological disorders * Women who are pregnant or may be pregnant * Unable to complete questionnaires, computerized tasks, or informed consent
Where this trial is running
Mashhad, Khorassan Razavi
- Ferdowsi University of Mashhad — Mashhad, Khorassan Razavi, Iran, Islamic Republic of (RECRUITING)
Study contacts
- Study coordinator: Ali Moghimi, PhD
- Email: moghimi@um.ac.ir
- Phone: 0098 09153176390
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obsessive-Compulsive Disorder, Contamination symptoms, Disgust, Evaluative Conditioning, Transcranial Direct Current Stimulation, Orbitofrontal Cortex