Reducing chemotherapy for HER2 positive breast cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the feasibility of de-escalating neoadjuvant chemotherapy regimens in patients with HER2 positive breast cancer. It focuses on comparing the standard combination of chemotherapy with targeted therapy against a single-agent chemotherapy approach. The study will involve patients diagnosed with stage II or III HER2 positive breast cancer who have received treatment at Peking University People's Hospital. The goal is to determine if a less intensive chemotherapy regimen can be effective while minimizing side effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\) Patients with HER2 positive breast cancer diagnosed by biopsy in Peking University People's Hospital;
* 2\) The clinical stage was stage II or stage III (i.e. T2 and above, and/or lymph node positive, without distant organ metastasis);
* 3\) Received treatment in our hospital and had hospitalization records;
* 4\) Has signed and agreed to participate in the PKUPH breast disease cohort study.

Exclusion Criteria:

* 1\) Lack of clinical and pathological data (such as imaging data and pathological data);
* 2\) Patients with metastatic breast cancer or bilateral breast cancer;
* 3\) At the same time, they received anti-tumor therapy in other clinical trials, including endocrine therapy and targeted therapy;
* 4\) Receiving other regimens besides the established neoadjuvant regimens

Where it's running

• Peking University People's Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: shu wang — Peking University People's Hospital
• Study coordinator: yuan peng, doctor
• Email: 13671287670@163.com
• Phone: 86+13671287670

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.