Reducing Blood Pressure and Lipids in Elderly Patients with Isolated Systolic Hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness and safety of blood pressure and lipid-lowering therapy in elderly patients with isolated systolic hypertension. It involves a 12-month prospective, randomized, active-controlled, open-label design with three treatment groups: amlodipine/atorvastatin, amlodipine alone, and a lifestyle intervention. The study aims to determine if these treatments can improve health outcomes in older adults who are typically untreated for this condition. Participants will be men and women aged 65 to 79 with specific blood pressure criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 65-79;
* Isolated systolic hypertension (office systolic blood pressure (SBP) ≥ 130 and \< 150 mmHg and office diastolic blood pressure (DBP) \< 80 mmHg) in untreated patients；
* Ability to understand the study requirements and provide informed consent.

Exclusion Criteria:

* Hypersensitivity history to any study drug or similar drug；
* Severe renal insufficiency (eGFR \< 30 mL/min/1.73m2);
* Hyperkalemia (serum potassium \> 5mmol/L);
* Active liver disease or hepatic insufficiency (AST or ALT \> 3 times upper limit of normal);
* History of malignancy over the past 5 years;
* Severe disease patients with life expectancy of \< 1 year;
* Previous or current diagnosis of heart failure;
* Stroke or myocardial infarction within 6 months;
* Previous or current atrial fibrillation, frequent ventricular premature beats, supraventricular tachycardia;
* Patients who are receiving other study drugs or study medical devices;
* Pregnant or lactating women;
* Other circumstances that patients are not appropriate for the study upon the investigator's judgment.

Where it's running

• Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
  Shanghai, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.