Rebound Pain After Knee Replacement: Does It Link to Long-Term Pain?
Official title: Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty: A Prospective Observational Study
Run by Konya City Hospital · NCT07511985 · Data updated 2026-11-12
This study tests whether rebound pain after a nerve block during knee replacement is linked to developing chronic pain later on.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 220 (estimated) |
| Sponsor | Konya City Hospital Academic / other |
| Locations | 1 site (Konya, Meram) |
| Status | Recruiting |
| Started | August 19, 2026 |
| Main results expected | December 12, 2026 |
| Study ends | December 12, 2026 |
| Registry record updated | August 20, 2026 |
| Trial ID | NCT07511985 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 and older scheduled for unilateral elective total knee arthroplasty under spinal anesthesia with a peripheral nerve block as part of routine care.
✕Probably not a fit
Patients without rebound pain or those whose pain trajectories do not influence chronic pain outcomes may see no direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study in adults undergoing unilevel total knee arthroplasty with spinal anesthesia and routine nerve block analgesia. Researchers will track rebound pain in the early postoperative period using pain diaries, numeric rating scales, and analgesic use, then assess chronic postsurgical pain and related outcomes at 3 and 6 months with validated measures for pain, neuropathic features, psychological status, function, and quality of life. No experimental treatments or additional procedures are involved beyond standard clinical care. The primary outcome is chronic postsurgical pain at 3 months.
Why it matters
Potential benefit: If rebound pain predicts chronic pain, clinicians could tailor analgesia and follow-up to reduce long-term pain and improve recovery.
How similar studies have gone: Previous research has begun to explore links between early rebound pain and later chronic pain in surgical settings, but evidence in knee arthroplasty remains limited and observational.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * ASA physical status I to III * Scheduled for unilateral elective total knee arthroplasty * Planned to undergo spinal anesthesia * Planned to receive a peripheral nerve block as part of routine multimodal analgesia * Able to provide informed consent and complete study assessments Exclusion Criteria: * Chronic opioid use (60 mg oral morphine equivalent per day or more, or use for 3 months or longer) * Significant neuropathy or radiculopathy * Bilateral or two-stage total knee arthroplasty during the same hospitalization * Contralateral total knee arthroplasty within the previous 6 months * Severe cognitive impairment or major psychiatric disorder * Chronic analgesic dependence
Where it's running
-
Mahmut TUTAR
Konya, Meram, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Mahmut Tutar, MD — Konya City Hospi̇tal
- Study coordinator: Mahmut Tutar, MD
- Email: masatu42@gmail.com
- Phone: +905552723704
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.