Real-world use of a new semaglutide form (oral and injectable) for adults with type 2 diabetes in Argentina

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, multicenter observational study evaluates the real-world effectiveness and safety of both oral and subcutaneous semaglutide in adults with type 2 diabetes in Argentina. Participants receive semaglutide as prescribed by their clinicians, with follow-up at 3, 6, and 12 months to track HbA1c, weight, waist circumference, hand-grip strength, treatment satisfaction, adherence, route switching, discontinuations, and adverse events. Outcomes include changes in HbA1c from baseline and secondary measures such as weight change and safety signals. The Diabetes Treatment Satisfaction Questionnaire and adherence assessments will be used to capture patient-reported experiences. No randomization or control group is involved; findings will reflect routine clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years.
* Clinical diagnosis of type 2 diabetes mellitus.
* Baseline glycated hemoglobin (HbA1c) \>7% and ≤12%.
* Initiating treatment with semaglutide (oral or subcutaneous) prescribed by the treating physician according to clinical judgment.

Exclusion Criteria:

* Pregnancy or lactation at the time of enrollment.
* History of severe hypersensitivity or adverse reactions to glucagon-like peptide-1 (GLP-1) receptor agonists.
* Contraindications to semaglutide as listed in the product label (e.g., severe gastrointestinal disease, certain endocrine tumors).
* Any other serious medical condition that, in the investigator's opinion, may interfere with study participation or data interpretation.

Where it's running

• Hospital Italiano de Buenos Aires
  Buenos Aires, Buenos Aires, Argentina Recruiting
• Hospital General de Agudos Dr Enrique Tornú
  Buenos Aires, Buenos Aires, Argentina Recruiting

Study contacts

• Principal investigator: María Natalia Nachón, MD — Hospital General de Agudos Dr Enrique Tornú
• Study coordinator: Martín L Gil Folgar, MD
• Email: martin.gilfolgar@hospitalitaliano.org.ar
• Phone: 1520497361

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.