Clinical trial Recruiting at 1 site Interventional Ages 20 to 80 Women only

Radiation therapy for endometrial cancer after surgery

Official title: Postoperative Hypofractionated Intensity-modulated Radiotherapy Endometrial Cancer: A Prospective Phase II Trial (POHIM_EM Trial)

Run by Samsung Medical Center · NCT05876130 · Data updated 2026-11-12

This study tests a new type of radiation therapy for women with stage III endometrial cancer after surgery to see if it helps them stay cancer-free as well as traditional treatments.

Quick facts

Study typeInterventional
Ages20 Years to 80 Years
SexWomen only
Enrollment92 (estimated)
SponsorSamsung Medical Center
Academic / other
Drugs / interventionschemotherapy, radiation
Locations1 site (Seoul)
StatusRecruiting
StartedNovember 1, 2022
Main results expectedDecember 31, 2031
Study endsDecember 31, 2031
Registry record updatedJune 12, 2024
Trial IDNCT05876130 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are women with histologically confirmed endometrioid type endometrial cancer who have completed surgery and are at FIGO stage III.

Probably not a fit

Patients with distant metastasis or those who have had previous pelvic radiotherapy will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of hypofractionated intensity-modulated whole pelvic radiation therapy in women with stage III endometrial cancer who have undergone curative surgery. The focus is on determining whether this treatment approach can achieve non-inferior disease-free survival compared to traditional methods. Participants will receive a specific radiation dose over a set number of fractions following their surgery. The study aims to provide insights into optimizing postoperative care for this patient population.

Why it matters

Potential benefit: If successful, this approach could improve disease-free survival rates for women with stage III endometrial cancer after surgery.

How similar studies have gone: Other studies have shown promise with hypofractionated radiation therapy in various cancers, suggesting potential for success in this approach for endometrial cancer.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* histologically confirmed endometrioid type endometrial cancer
* completion of hysterectomy and surgical staging
* pathologically confirmed FIGO stage III
* ECOG performance status 0 or 1
* adjuvant chemotherapy was done or planned

Exclusion Criteria:

* presence of distant metastasis
* previous history of pelvic radiotherapy
* severe and unstable medical condition
* previous history of other carcinoma except for thyroid cancer, skin cancer, and endometrial cancer

Where it's running

  • Samsung Medical Center
    Seoul, South Korea
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.