Quality of life during the transition to home versus in-center dialysis
Official title: Prospective Changes in Quality of Life and Frailty in Chronic Kidney Disease Patients Transitioning to Home Versus In-Center Dialysis (QUALIFY CKD-to-HOME Study)
Run by Ciusss de L'Est de l'Île de Montréal · NCT06458322 · Data updated 2026-11-12
This project will see if people with advanced CKD who start home dialysis have better quality of life and less frailty over the first year than those who start in-center hemodialysis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Ciusss de L'Est de l'Île de Montréal Academic / other |
| Locations | 1 site (Montreal, Quebec) |
| Status | Recruiting |
| Started | July 1, 2022 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | February 23, 2026 |
| Trial ID | NCT06458322 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults followed in advanced CKD clinics with eGFR ≤12 mL/min/1.73 m2 who can consent and speak English or French, not planning conservative care or imminent transplant, and with limited prior dialysis exposure are ideal candidates.
✕Probably not a fit
Patients planning conservative management, with planned kidney transplant within six months, with severe cognitive or psychiatric inability to consent, with prior long-term dialysis, or with life expectancy under six months are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
QUALIFY CKD-to-HOME is a prospective cohort of about 200 adults followed at seven Canadian centers with active patient-partner engagement. Participants are followed every three months beginning at eGFR ≤12 mL/min/1.73 m2 and continue through the first 12 months after dialysis start. The study compares trajectories of quality of life, frailty, and other patient-reported outcomes (fatigue, anxiety and depression, general assessment, cognition) between people oriented toward home dialysis and those starting in-center hemodialysis. Analyses will seek predictors of severe decline in these outcomes during advanced CKD follow-up and after dialysis initiation.
Why it matters
Potential benefit: If successful, the findings could help patients and clinicians set realistic expectations about quality of life and frailty changes after starting home versus in-center dialysis and guide modality decisions.
How similar studies have gone: Most prior research on dialysis modality has emphasized mortality and hospitalizations rather than PROMs and frailty, so directly comparable evidence on PROM trajectories is limited and this approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients followed in advanced CKD clinic; * eGFR ≤12 mL/min/1.73m2 96; * Understand English or French. Exclusion Criteria: * Orientation toward conservative treatment; * Planned kidney transplantation \< 6 months; * Unable to provide consent due to severe cognitive or psychiatric disease; * Previous treatment with dialysis \> 3 month; * Life expectancy \< 6 months.
Where it's running
-
Hôpital Maisonneuve-Rosemont
Montreal, Quebec, Canada Recruiting
Study contacts
- Principal investigator: Annie-Claire Nadeau-Fredette, MD — Ciusss de L'Est de l'Île de Montréal
- Study coordinator: Émilie Robitaille, Bac Sc. Inf.
- Email: emilie.robitaille.cemtl@ssss.gouv.qc.ca
- Phone: 514-252-3400
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.