Pyeloplasty in kids with very low kidney function

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows pediatric patients with ureteropelvic junction obstruction and severely reduced differential renal function (less than 10%) who undergo pyeloplasty. It aims to track postoperative kidney function, changes in hydronephrosis on imaging, and clinical outcomes such as symptom relief and complications. Historically, kidneys with DRF below 10% were often removed, but recent data suggest potential for recovery after reconstructive surgery. The study will report on functional, radiographic, and clinical outcomes over the follow-up period. Eligible participants are children aged 1 month to 18 years with UPJO and a normal opposite kidney.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 1 month to 18 years.
* Diagnosis of primary ureteropelvic junction obstruction.
* Preoperative differential renal function \<10% on MAG3 renogram.
* A normal contralateral kidney.

Exclusion Criteria:

* Secondary Ureteropelvic Junction Obstruction (UPJO) (postoperative, traumatic, or secondary to other anomalies).
* Solitary functioning kidney.
* Associated vesicoureteral reflux or posterior urethral valves.
* Severe comorbidities affecting renal function.
* Incomplete medical records.

Where it's running

• Tanta University
  Tanta, El-Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Yossof H Abdul-Qader, MBBCH
• Email: Youssifhamed812@gmail.com
• Phone: 00201005669720

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.