Pulsatile hormone administration's effect on insulin action
Effect of Pulsatile Hormone Administration on Insulin Action
This study tests whether giving insulin in a steady way or in bursts helps people with obesity and insulin resistance use insulin better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 12 (estimated) |
| Ages | 50 Years to 75 Years |
| Sex | All |
| Sponsor | Pennington Biomedical Research Center Academic / other |
| Locations | 1 site (Baton Rouge, Louisiana) |
| Trial ID | NCT06216665 on ClinicalTrials.gov |
What this trial studies
This study investigates how different methods of insulin administration affect insulin sensitivity in individuals with obesity and insulin resistance. Participants who have completed a prior study will undergo two hyperinsulinemic euglycemic clamp tests, one with continuous insulin infusion and another with pulsatile insulin infusion. The goal is to compare the effectiveness of these two methods in maintaining insulin sensitivity. Blood samples will be collected to measure glucose and insulin levels following the tests.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with obesity and insulin resistance who have completed the Motivate study.
Not a fit: Patients who have not completed the end-of-study hyperinsulinemic euglycemic clamp test of the Motivate study will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved insulin sensitivity management strategies for patients with obesity and insulin resistance.
How similar studies have performed: While the approach of pulsatile insulin administration is being explored, the specific comparison of continuous versus pulsatile administration in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Completion of the Motivate Study (NCT05649176) Exclusion Criteria: * Non-completion of the end-of-study hyperinsulinemic euglycemic clamp test of the Motivate study
Where this trial is running
Baton Rouge, Louisiana
- Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States (Recruiting)
Study contacts
- Principal investigator: Candida Rebello, PhD — Pennington Biomedical Research Center
- Study coordinator: Candida J Rebello, Ph.D.
- Email: Candida.Rebello@pbrc.edu
- Phone: 225-763-3159
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.