Psychedelic virtual reality therapy for clinical depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research explores the therapeutic potential of psychedelic-like experiences simulated through virtual reality (VR) for patients suffering from clinical depression. The study is divided into two arms: one utilizing 'Psyrreal,' a VR experience designed to replicate psychedelic effects, and the other using 'Routine Realms,' a control VR experience without psychedelic elements. The primary goal is to assess how these experiences influence depressive symptoms in a clinical population. Participants will undergo a comprehensive psychiatric evaluation to confirm eligibility based on persistent depressive symptoms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Persistent depressive symptoms observed during the initial screening and confirmed at baseline, as determined through a comprehensive psychiatric evaluation.
* Provision of written informed consent by the participant.
* Fluent in Estonian as a native language.

Exclusion Criteria:

* Presence of significant impairments in vision, hearing, or balance.
* Active suicidal ideation or current engagement in self-harm behaviors. Note: Individuals meeting this criterion will be directed to suitable crisis intervention services.
* Established diagnosis of bipolar disorder.
* Manifestation of psychotic symptoms.
* History of schizophrenia, either personally or within two generations of the family lineage.
* Ongoing diagnosis of epilepsy, dementia, or any other neurological condition that could interfere with the effective utilization of virtual reality (VR) technology.
* Susceptibility to motion sickness.

Where it's running

• Confido Medical Centre
  Tallinn, Harju, Estonia Recruiting

Study contacts

• Principal investigator: Jaan Aru, PhD — University of Tartu
• Study coordinator: Karl Kristjan Kaup, MSc
• Email: kaup.kristjan@gmail.com
• Phone: +372 5342 8489

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.