Protective effect of lactation on gestational diabetes in a future pregnancy
Official title: Protective Effect of Lactation Against Gestational Diabetes Mellitus in Subsequent Pregnancy: A Prospective Observational Cohort Study
Run by Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · NCT07624968 · Data updated 2026-11-12
This observational study tests whether lactation around the time of a first pregnancy is linked to a lower risk of gestational diabetes in a subsequent pregnancy for women who conceive while lactating.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | Women only |
| Enrollment | 140 (estimated) |
| Sponsor | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization Academic / other |
| Locations | 2 sites (Istanbul and 1 other locations) |
| Status | Recruiting |
| Started | January 15, 2026 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | June 3, 2026 |
| Trial ID | NCT07624968 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pregnant individuals aged 18-50 with singleton pregnancies who conceived during lactation and have complete glycemic and ultrasound data.
✕Probably not a fit
Pregnant individuals not lactating at conception or lacking complete glycemic/ultrasound data may not experience the same potential benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective cohort study will follow pregnant women aged 18-50 who conceive during lactation to see if lactation is associated with later gestational diabetes and related pregnancy outcomes. Researchers will collect routine glycemic markers (fasting glucose, HbA1c, glycosuria, OGTT) and ultrasound measurements (fetal size and amniotic fluid indices) during antenatal care. The study aims to clarify whether lactation is linked to improved maternal glucose metabolism and potentially reduced GDM risk in future pregnancies. Findings could inform counseling on lactation as part of maternal health strategies.
Why it matters
Potential benefit: If lactation is protective, findings could support recommendations for longer or more exclusive breastfeeding as part of maternal health optimization.
How similar studies have gone: Previous studies suggest metabolic benefits of lactation, but evidence specifically linking lactation to reduced GDM risk in a subsequent pregnancy is limited and this study explores that association.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant individuals aged 18 to 50 years. * Singleton pregnancy. * Conception during the lactation period. * Follow-up at Prof. Dr. Cemil Taşcıoğlu City Hospital or Esenyurt Necmi Kadıoğlu State Hospital. * Availability of glycemic parameters including fasting plasma glucose, HbA1c, glycosuria, and 75-g oral glucose tolerance test (OGTT) results. * Availability of routine ultrasonographic measurements including fetal abdominal circumference percentile (AC), estimated fetal weight percentile (EFW), and amniotic fluid index (AFI). Exclusion Criteria: * Age below 18 years. * Age above 50 years. * Multiple pregnancy. * Known chronic systemic disease or pre-existing diabetes mellitus. * Missing clinical, laboratory, or ultrasonographic data.
Where it's running
-
Prof. Dr. Cemil Taşcıoğlu City Hospital
Istanbul, Turkey (Türkiye) Recruiting -
Esenyurt Necmi Kadıoğlu State Hospital
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Burak D AYDOGDU, MD, OB/GYN
- Email: burakd.1992@hotmail.com
- Phone: +90 5396182228
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.