Metformin vs glyburide for blood sugar in gestational diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized phase 4 trial compares two oral medicines, metformin and glyburide, for managing blood glucose in pregnant women with gestational diabetes who require drug therapy. Participants are 18 to 45 years old with singleton pregnancies and GDM diagnosed between 13 and 33 weeks; they are assigned to either metformin with dose adjustments up to 2,550 mg daily or glyburide with dose adjustments up to 20 mg daily. The primary question is which treatment has a lower rate of treatment failure, defined by the study protocol. Blood glucose levels will be monitored to guide dose adjustments and evaluate outcomes. The trial is sponsored by Nishtar Medical University, with sites at Nishtar Medical University and Hospital in Multan, Pakistan.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Gestational diabetes requiring drug treatment
* Gestational age between 13 - 33 weeks based on history and obstetric ultrasonography

Exclusion Criteria:

* Known cases of diabetes mellitus
* Serum creatinine \> 1.2 mg / dl
* Chronic liver disease
* Hypersensitivity to study medications

Where it's running

• Nishtar Medical University and Hospital
  Multan, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Iqra M Principal Investigator, MBBS
• Email: iqramahmoodjatoi321@gmail.com
• Phone: +92 306 1324121

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.