Prophylactic antibiotics to prevent surgical infections after hepatobiliary surgery in high-resistance settings

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In settings with high antimicrobial resistance, this pragmatic trial compares two preoperative antibiotic strategies for hepatobiliary surgery. Patients receive either piperacillin-tazobactam or the standard cefuroxime for perioperative infection prevention. The study aims to see if the broader beta-lactam/beta-lactamase inhibitor combination lowers surgical site infection rates without introducing undue safety concerns. Eligibility includes adults undergoing elective hepatobiliary surgery who can provide informed consent. Exclusions apply to beta-lactam allergies, active preoperative infections, certain immunosuppressive treatments, organ failure, pregnancy, and concurrent trial participation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients aged ≥18 years;
* Deemed eligible for elective hepatobiliary surgery;
* Demonstrated comprehension of the study nature and expressed willingness to comply with trial procedures;
* Capable of providing written informed consent.

Exclusion Criteria:

* History of β-lactam allergy or hypersensitivity
* Uncontrolled preoperative infection;
* Current or recent (within the preceding month) systemic corticosteroid administration;
* Severe hepatic or renal impairment;
* Pregnancy or lactation;
* Concurrent enrolment in another clinical trial;
* Any other condition deemed by the investigator to render the patient unsuitable for study participation.

Where it's running

• Nanjing Drum Tower Hospital
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Dayu Chen, Pharmacist in Charge, PharmD
• Email: cdy_pharmacy@njglyy.com
• Phone: +86-025-83106666-60924

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.