Prone positioning for adults with moderate-to-severe ARDS in the ICU

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will use a registry-based observational approach at a single tertiary hospital to collect clinical data on adults with moderate-to-severe ARDS receiving invasive mechanical ventilation. Eligible patients meet PaO2/FiO2 ≤150 mm Hg, PEEP ≥5 cm H2O, and ARDS defined by the 2023 Global Definition. The study will describe practice patterns, patient outcomes, and safety signals with prone position ventilation, and will explore whether chest CT–defined lung morphology (focal vs non-focal) modifies response. As an observational, single-center investigation, it will report associations and hypothesis-generating findings rather than prove causation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1.Age ≥ 18 years 2. Moderate-to-severe ARDS requiring invasive mechanical ventilation, defined as:

1. PaO₂/FiO₂ ≤ 150 mm Hg,
2. PEEP ≥ 5 cm H₂O,
3. ARDS diagnosed according to the 2023 Global Definition.

Exclusion Criteria:

1.Refusal of informed consent by the patient's legally authorized representative

Where it's running

• Zhongda Hospital, School of Medicine, Southeast University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Hui Chen, MD
• Email: huichen.icu@gmail.com
• Phone: +8618006138640

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Right‑heart function and heart–lung interaction during ARDS with mechanical ventilation

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• Umbilical‑cord mesenchymal stem cell and secretome therapy for severe ARDS

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• Human umbilical cord mesenchymal stem cell injection for moderate to severe ARDS

  This will test whether a single injection of human umbilical cord mesenchymal stem cells can help adults with moderate to severe ARDS that hasn't improved after standard treatment.

  Recruiting Phase 1/2 Changchun Tuohua Pharmaceutical Co., Ltd. · Wuhan, Hubei · NCT07413978

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.