Prolonged vaginal progesterone to help prevent preterm birth after IVF with fresh embryos

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study examines whether prolonging vaginal progesterone from the time of a positive pregnancy test through 24 weeks of gestation lowers preterm birth risk in singleton pregnancies after fresh IVF embryo transfer. Participants are adults aged 20–40 with an ART indication and singleton pregnancies, randomized to receive progesterone until 24 weeks vs. until 12 weeks with ongoing monitoring. Outcomes include preterm birth incidence and cervical length assessments via ultrasound at specified gestational ages. Safety and adherence are monitored, with follow-up through delivery.

Why it matters

Who can join: the full rules

Inclusion criteria are: age 20-40 years; meeting the indications for assisted reproductive technology (ART) and undergoing fresh embryo transfer with in vitro fertilization (IVF); singleton pregnancy; and willingness to participate and provide written informed consent.

Exclusion criteria are: age \>40 years; history of second-trimester miscarriage or cervical insufficiency; ovarian dysfunction or relevant surgical history; uterine malformation; diseases associated with abnormal uterine cavity morphology; abnormal cervical morphology or function, or history of cervical surgery; refractory vaginitis; multiple pregnancy; concomitant severe medical or surgical diseases; participation in another clinical trial within 90 days prior to randomization, or use of an investigational drug within 30 days; inability to complete long-term follow-up or poor compliance; and any other condition that, in the investigator's judgment, may affect trial implementation or outcome evaluation.

Where it's running

• Sun Yat-sen Memorial Hospital
  Guangzhou, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.