Progressive Blood Flow Restriction Exercises After Total Knee Replacement
Official title: Effects of Progressive Restricted Blood Flow Exercise on Pain, Range of Motion, Swelling, Proprioception and Kinesiophobia on Patients With Total Knee Arthoplasty
Run by Lahore University of Biological and Applied Sciences · NCT07601906 · Data updated 2026-11-12
In people aged 50–65 who had a knee replacement, this study tests whether adding progressive blood flow restriction exercises to standard physical therapy helps recovery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years to 65 Years |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | Lahore University of Biological and Applied Sciences Academic / other |
| Locations | 1 site (Lahore, Punjab Province) |
| Status | Recruiting |
| Started | May 25, 2026 |
| Main results expected | October 31, 2026 |
| Study ends | November 20, 2026 |
| Registry record updated | June 9, 2026 |
| Trial ID | NCT07601906 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 50–65 years old who had a primary unilateral TKA for osteoarthritis, experience mild to moderate pain after surgery, and can actively move the knee with at least 30° flexion.
✕Probably not a fit
Patients with recent deep vein thrombosis, severe cardiovascular conditions, vascular disease, active infection, or significant neurological impairment may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, single-blind trial compares progressive blood flow restriction (BFR) exercise plus conventional physical therapy to conventional physical therapy alone after unilateral total knee arthroplasty. The goal is to see if BFR can improve pain, range of motion, swelling, and function without excessive joint stress. Participants will be adults with mild to moderate postoperative pain and specific knee motion criteria, recruited from a Lahore, Pakistan site. Outcomes will include pain levels, knee flexion, swelling, and proprioception, among other functional measures. The trial uses a two-arm parallel design to evaluate the added value of BFR in the early rehabilitation period.
Why it matters
Potential benefit: If successful, patients may regain knee function faster with less pain and swelling using lower-load exercises.
How similar studies have gone: Previous research supports BFR for improving muscle strength; effects on other outcomes after TKA are less established, making this study relatively novel in broader outcome assessment.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients of age 50-65 years. 2. Primary unilateral TKA due to osteoarthritis. 3. Individuals with mild to moderate postoperative pain (NPRS score 4-7). 4. Minimum active knee flexion of 30° \& an extension lag of no more than 15°. 5. Patients should be medically stable, cognitively able to follow instructions in Urdu or english, and willing to provide written informed consent Exclusion Criteria: 1. History of deep vein thrombosis within the last six months. 2. Peripheral vascular disease and active infection. 3. Severe cardiovascular conditions 4. Neurological disorders affecting lower limb function
Where it's running
-
Saleem Memorial Trust Hospital
Lahore, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Umber Nawaz
- Email: Umber.nawaz@ubas.edu.pk
- Phone: +92 333 4888279
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Foam rolling after knee replacement
This study tests whether adding foam rolling to the standard rehabilitation helps people recover after total knee arthroplasty.
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Comparing femoral triangle and adductor canal nerve blocks for early quadriceps function after knee replacement
This test compares two nerve blocks — femoral triangle block and adductor canal block — to see which causes less early quadriceps weakness in adults having a single knee replacement.
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Mir Shakeel teleintegrated therapy for recovery after total knee replacement
This trial will test whether a structured telerehabilitation program (MSTITP) helps people aged 50–65 recover better after primary total knee replacement compared with standard in-person physiotherapy.
-
Balance training with the Tecnobody ProKin after total knee replacement
This will test whether adding balance training on the Tecnobody ProKin platform helps people recovering from total knee replacement regain balance, strength, and walking ability better than standard rehabilitation alone.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.