Clinical trial No longer in our active list Observational Ages 18 to 80

Prognosis assessment for patients with acute-on-chronic liver failure

Official title: The Investigate Outcomes and Prognostic Factors of Patients With Acute-on-chronic Liver Failure

Run by Xiangya Hospital of Central South University · NCT05393453 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study looks at patients with chronic liver disease who suddenly develop liver failure to see how their condition affects their short-term and long-term health outcomes.

More Acute-On-Chronic Liver Failure trials

Quick facts

Study typeObservational
Ages18 Years to 80 Years
SexAll
Enrollment500 (estimated)
SponsorXiangya Hospital of Central South University
Academic / other
Locations1 site (Changsha, Hunan)
Trial IDNCT05393453 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients with chronic liver disease who are experiencing acute liver failure.

Probably not a fit

Patients without chronic liver disease or those with hepatocellular carcinoma will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze the clinical data of patients with chronic liver disease who experience acute liver failure, focusing on their prognosis. Conducted at Xiangya Hospital of Central South University, the study will collect various clinical examination indexes, including blood tests and imaging, to evaluate short-term and long-term outcomes. Patients will receive routine treatment without any additional interventions, and their complications and prognoses will be recorded. Blood, urine, and stool samples will also be collected for potential future testing.

Why it matters

Potential benefit: If successful, this study could improve the understanding of prognosis in patients with acute-on-chronic liver failure, potentially guiding treatment decisions.

How similar studies have gone: While there have been studies on liver failure, this specific approach focusing on prognosis using severity scores is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patients with evidence of chronic liver disease patients with liver failure

Exclusion Criteria:

* Patients who do not have chronic liver disease Patients who have hepatocellular carcinoma Patients who admitted for extrahepatic manifestations Patients who have HIV infection Patients who admitted for symptomatic control of chronic liver disease, other than acute deterioration of liver function

Where it's running

  • Xiangya Hospital
    Changsha, Hunan, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.