Prilocaine versus lidocaine for sphenopalatine ganglion block during endoscopic pituitary surgery
Bilateral Sphenopalatine Ganglion Block Using Prilocaine Versus Lidocaine as Adjuvants to General Anesthesia During Endoscopic Hypophysectomy, Randomized Trial.
This test sees if using prilocaine instead of lidocaine for a sphenopalatine ganglion block helps keep blood pressure steadier and reduces pain for adults aged 21–45 having endoscopic removal of a pituitary adenoma.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 54 (estimated) |
| Ages | 21 Years to 45 Years |
| Sex | All |
| Sponsor | Kasr El Aini Hospital Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT07188987 on ClinicalTrials.gov |
What this trial studies
Patients having endoscopic hypophysectomy will receive a sphenopalatine (pterygopalatine fossa) ganglion block with either prilocaine or lidocaine given perioperatively. The study compares intraoperative hemodynamic stability, quality of the surgical field (bleeding), and opioid/analgesic requirements between the two local anesthetics. Eligible adults (ASA I–II, 21–45 years) are recruited at Kasr El Ainy Hospital and treated during their scheduled surgery. Outcomes include blood pressure changes during key surgical steps, surgeon-rated field visibility, and postoperative analgesia use.
Who should consider this trial
Good fit: Ideal candidates are adults 21–45 years old with pituitary adenoma scheduled for endoscopic hypophysectomy who are ASA physical status I–II and not taking anticoagulants or NSAIDs.
Not a fit: Patients outside the 21–45 age range, with uncontrolled hypertension, coagulopathy, increased intracranial pressure, significant liver or kidney disease, or on anticoagulants/NSAIDs are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the intervention could reduce intraoperative blood pressure swings, lower bleeding in the surgical field, and decrease opioid needs during and after surgery.
How similar studies have performed: Limited prior reports of sphenopalatine ganglion block in pituitary surgery have shown promising results for hemodynamic control and field quality, but direct comparisons of prilocaine versus lidocaine are novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with pituitary adenoma undergoing endoscopic hypophysectomy. * ASA physical status I and II. * Age above 21, below 45 years. * Male or female Exclusion Criteria: * Any patient below 21 years or above 45 years. * Patients suffering from any of the following conditions: * Disturbed conscious level. * Coagulation abnormalities. * Poorly controlled blood pressure and/or heart rate. * Increased intracranial tension. * Liver and kidney disorders. * Patients on anticoagulants and/or NSAIDS (non-steroidal anti- inflammatory drugs * Patients addicted to drugs and/or alcohol. * Patients with disturbed conscious level at the end of the surgery, GCS \>14
Where this trial is running
Cairo
- Kasr El Ainy — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Rania Fahmy, Associate Professor
- Email: ransam98@gmail.com
- Phone: +201270820372
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.