Prilocaine versus lidocaine for sphenopalatine ganglion block during endoscopic pituitary surgery
Official title: Bilateral Sphenopalatine Ganglion Block Using Prilocaine Versus Lidocaine as Adjuvants to General Anesthesia During Endoscopic Hypophysectomy, Randomized Trial.
Run by Kasr El Aini Hospital · NCT07188987 · Data updated 2026-11-12
This test sees if using prilocaine instead of lidocaine for a sphenopalatine ganglion block helps keep blood pressure steadier and reduces pain for adults aged 21–45 having endoscopic removal of a pituitary adenoma.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years to 45 Years |
| Sex | All |
| Enrollment | 54 (estimated) |
| Sponsor | Kasr El Aini Hospital Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | December 1, 2025 |
| Main results expected | February 2026 |
| Study ends | February 2026 |
| Registry record updated | December 5, 2025 |
| Trial ID | NCT07188987 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 21–45 years old with pituitary adenoma scheduled for endoscopic hypophysectomy who are ASA physical status I–II and not taking anticoagulants or NSAIDs.
✕Probably not a fit
Patients outside the 21–45 age range, with uncontrolled hypertension, coagulopathy, increased intracranial pressure, significant liver or kidney disease, or on anticoagulants/NSAIDs are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Patients having endoscopic hypophysectomy will receive a sphenopalatine (pterygopalatine fossa) ganglion block with either prilocaine or lidocaine given perioperatively. The study compares intraoperative hemodynamic stability, quality of the surgical field (bleeding), and opioid/analgesic requirements between the two local anesthetics. Eligible adults (ASA I–II, 21–45 years) are recruited at Kasr El Ainy Hospital and treated during their scheduled surgery. Outcomes include blood pressure changes during key surgical steps, surgeon-rated field visibility, and postoperative analgesia use.
Why it matters
Potential benefit: If successful, the intervention could reduce intraoperative blood pressure swings, lower bleeding in the surgical field, and decrease opioid needs during and after surgery.
How similar studies have gone: Limited prior reports of sphenopalatine ganglion block in pituitary surgery have shown promising results for hemodynamic control and field quality, but direct comparisons of prilocaine versus lidocaine are novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with pituitary adenoma undergoing endoscopic hypophysectomy. * ASA physical status I and II. * Age above 21, below 45 years. * Male or female Exclusion Criteria: * Any patient below 21 years or above 45 years. * Patients suffering from any of the following conditions: * Disturbed conscious level. * Coagulation abnormalities. * Poorly controlled blood pressure and/or heart rate. * Increased intracranial tension. * Liver and kidney disorders. * Patients on anticoagulants and/or NSAIDS (non-steroidal anti- inflammatory drugs * Patients addicted to drugs and/or alcohol. * Patients with disturbed conscious level at the end of the surgery, GCS \>14
Where it's running
-
Kasr El Ainy
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Rania Fahmy, Associate Professor
- Email: ransam98@gmail.com
- Phone: +201270820372
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Smartphone app to help follow the 2024 KDIGO chronic kidney disease guidelines
This project will test whether a smartphone app helps young adults (ages 16–29) with chronic kidney disease follow the 2024 KDIGO guideline recommendations.
-
Treating elevated blood pressure during hospital stays to see if it changes outcomes
We are testing whether changing how hospitals respond to briefly high blood pressure in adults on general medical units reduces unnecessary increases in blood-pressure medicines and improves patient outcomes.
-
Can switching to a prebiotic soda improve blood sugar in adults who regularly drink soda
This study tests whether replacing usual non-diet soda with OLIPOP prebiotic soda for 8 weeks can improve blood sugar control in adults with glucose dysregulation who regularly drink soda.
-
Effects of Cool Roofs on Health and Indoor Environments
This study is testing if special cool roofs that reflect sunlight can help people living in hot urban areas feel better and stay healthier by reducing heat exposure.
-
SugarLock peanut skin extract before meals to see if it helps post-meal blood sugar in healthy adults
This study tests whether taking SugarLock peanut skin extract (and white kidney bean extract) before a meal can blunt or delay rises in blood glucose in healthy adults.
-
Overnight Temperature Regulation to Test Gut Health, Inflammation, and Circadian Rhythms
This study tests whether two weeks of using the Eight Sleep Pod at night can improve gut bacteria balance, lower inflammation, and strengthen daily temperature and blood pressure rhythms in postmenopausal women and age-matched men with poor sleep.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.