Preventive removal or staged removal of fallopian tubes and ovaries for women with hereditary ovarian cancer risk

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This bidirectional cohort combines retrospective data starting in 2020 with a prospective follow-up of at least five years to compare different prophylactic surgical paths chosen by patients and their doctors. Participants who are carriers of pathogenic or likely pathogenic variants in genes such as BRCA1/2, RAD51C/D, BRIP1, or PALB2 will be grouped by standard risk-reducing salpingo-oophorectomy (RRSO), prophylactic salpingectomy with delayed oophorectomy (PSDO), or close monitoring. Researchers will collect clinical records, surgical pathology, ovarian function measures, and quality-of-life and psychological assessments to compare cancer incidence, safety, and life impact across groups. The goal is to identify whether individualized surgical strategies can lower cancer risk while minimizing adverse effects on hormonal function and quality of life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Gender: Female. Age: 18 years or older at the time of enrollment.Genetic Risk: Documented carriers of pathogenic or likely pathogenic germline mutations in high-risk ovarian cancer susceptibility genes (including BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2). Data Availability: Willing to provide informed consent and allow access to clinical records, genetic testing reports, and follow-up data (bidirectional cohort). Psychosocial Status: Ability to complete quality of life and psychological assessment scales (e.g., GCS, SF-36, FSFI).

Exclusion Criteria:

* Prior Malignancy: History of ovarian, fallopian tube, or primary peritoneal cancer prior to the baseline intervention. Synchronous Malignancy: Diagnosis of any other advanced-stage malignancy. Inability to Follow-up: Significant psychological, social, or geographical factors that would prevent regular long-term follow-up (3 years). Previous Extensive Pelvic Surgery: History of extensive pelvic surgery that precludes the feasibility of laparoscopic prophylactic salpingectomy or oophorectomy.

Where it's running

• Peking University Third Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Associate Chief Physician/Associate Consultant, Doctor
• Email: yuanli@bjmu.edu.cn
• Phone: 18610689868

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.