Preventing peanut allergy through skin exposure and processing methods
TRANS-FOODS: Preventing Peanut Allergy Through Improved Understanding of the Transcutaneous Sensitisation Route, Novel Food Processing and Skin Care Adaptations
NA · King's College London · NCT05407012
This study is testing if rubbing peanut proteins on the skin can trigger allergies in people with skin issues, and whether using a special cream can help protect against this.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | King's College London (other) |
| Locations | 1 site (London) |
| Trial ID | NCT05407012 on ClinicalTrials.gov |
What this trial studies
This project investigates how peanut allergens interact with the skin, particularly in individuals with skin barrier defects. It aims to determine if peanut proteins can penetrate the skin through massage and whether this effect is heightened in those with conditions like atopic dermatitis. The study will also explore the detection of peanut proteins in skin fluid and their potential to activate immune responses in allergic individuals. Additionally, it will assess if using a barrier-enhancing cream can reduce the absorption of these allergens through the skin.
Who should consider this trial
Good fit: Ideal candidates include healthy adults and those with dry skin or atopic dermatitis who are willing to participate in the study.
Not a fit: Patients with a history of peanut allergy or those who have a positive skin prick test to peanuts will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new strategies for preventing peanut allergies, particularly in vulnerable populations.
How similar studies have performed: While the focus on cutaneous allergen exposure is relatively novel, similar studies have shown promise in understanding food allergies and their prevention.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult healthy volunteers (50% of the cohort), and adults with dry skin and AD (fulfilling the refined Hanifin and Rajka criteria, 50% of the cohort). * Willingness to apply the study intervention and to not use any other topical preparations over theforearms during the study period. Exclusion Criteria: * History of peanut allergy. * Positive skin prick test to peanut (\>0 mm). * No regular consumption of peanut products. * Widespread AD, in particular if this involves the test sites of the forearms.
Where this trial is running
London
- Unit for Population-Based Dermatology Research — London, United Kingdom (RECRUITING)
Study contacts
- Principal investigator: Carsten Flohr — King's College London
- Study coordinator: Stuart Jones
- Email: stuart.jones@kcl.ac.uk
- Phone: 0207 848 4506
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Allergy, Food, Food Allergy Peanut, Pathways and Sources of Exposure, Food safety, Public health, Dermatology, Food manufacture