Preventing low platelet counts in cancer patients undergoing chemotherapy

A Single-arm, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetic, Pharmacodynamics and Immunogenicity of PN20 for the Prevention of Chemotherapy-induced Thrombocytopenia in Patients With Lymphoma or Solid Tumor

This study is testing a new treatment called PN20 to see if it can help prevent low platelet counts in adults with lymphoma or solid tumors who are getting chemotherapy.

Quick facts

• Phase: PHASE1
• Study type: Interventional
• Enrollment: 24 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Chongqing Peg-Bio Biopharm Co., Ltd. (industry)
• Drugs / interventions: chemotherapy, cyclophosphamide, doxorubicin, prednisone
• Locations: 6 sites (Baoding, Hebei and 5 other locations)
• Trial ID: NCT06521931 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the safety and tolerability of PN20, a new treatment aimed at preventing chemotherapy-induced thrombocytopenia in adult patients with lymphoma or solid tumors. Participants will receive subcutaneous injections of PN20 before their chemotherapy sessions and will be monitored over several days for safety and effectiveness. The study is designed as a multicenter, single-arm, open-label, dose escalation approach, allowing for both single and multiple doses of PN20 based on patient response. The trial aims to determine if PN20 can effectively prevent low platelet counts during chemotherapy.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older diagnosed with lymphoma or solid tumors who are currently undergoing a 21-day chemotherapy regimen.

Not a fit: Patients who are not currently receiving chemotherapy or have platelet counts outside the specified range may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly reduce the incidence of chemotherapy-induced thrombocytopenia, improving patient outcomes and quality of life.

How similar studies have performed: While this approach is novel, similar studies targeting chemotherapy-induced side effects have shown promise in improving patient outcomes.

Eligibility criteria

Inclusion Criteria:

1. Aged ≥ 18 years, regardless of gender;
2. Diagnosed with lymphoma or solid tumor by pathological histology or cytology examination;
3. Currently receiving a 21-day chemotherapy regimen, using one or more of the following or similar drugs: gemcitabine; platinums, including carboplatin, nedaplatin, cisplatin, lobaplatin, etc.; anthracyclines, including doxorubicin, daunorubicin, epirubicin, etc.; taxanes, including paclitaxel, docetaxel, etc.; alkylating agents, including cyclophosphamide, ifosfamide, etc.;
4. The current chemotherapy regimen should be consistent with that of the previous chemotherapy cycle before enrollment, including the type and dosage of the drugs, and no medication or dosage adjustments are allowed;
5. Platelet count (PLT) was between 75 and 150×10\^9/L (including the critical value) one day before the start of chemotherapy in the first treatment cycle or before enrollment;
6. There was a decrease in PLT to 25×10\^9/L≤ PLT \<75×10\^9/L during the previous chemotherapy cycle before enrollment;
7. Expected survival ≥ 12 weeks;
8. Eastern Cooperative Oncology Group (ECOG) Physical Score is ≤ 2;
9. No fertility plan during the trial and within 6 months after the end of the follow-up, and agree to take medically recognized contraceptive measures (such as complete abstinence, condoms, contraceptive rings, ligation, drug contraception, etc.) to avoid pregnancy for themselves or their partners;
10. Be able to understand the requirements and procedures of the protocol, voluntarily participate and sign the informed consent form.

Exclusion Criteria:

1. With thrombocytopenia caused by non-chemotherapy within 6 months before screening, including but not limited to ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia, hypersplenism, infection and bleeding;
2. With other hematopoietic diseases other than lymphoma and chemotherapy induced thrombocytopenia, including leukemia, primary immune thrombocytopenia, myeloproliferative diseases, multiple myeloma and myelodysplastic syndrome;
3. The tumor has already undergone bone marrow invasion or metastasis;
4. With active central nervous system metastasis (such as clinical symptoms, cerebral edema, requiring hormone intervention (excluding maintenance of low-dose hormones)), progression of brain metastasis, and carcinomatous meningitis. Subjects with previously treated brain metastases who meet the following conditions may participate in the study: clinical stability has been maintained for ≥ 2 months, and systemic hormone therapy (prednisone or other equivalent doses of hormones at a dose of \>10 mg/day) has been discontinued for \>4 weeks;
5. Acute or active bleeding of clinical significance (such as gastrointestinal or central nervous system) within 7 days before screening;
6. Have a history of any arteriovenous thrombosis within 6 months before screening;
7. Have a history of major cardiovascular disease within 6 months before screening (such as congestive heart failure (New York Heart Association (NYHA) heart function score III-IV), arrhythmias known to increase the risk of thromboembolic events (atrial fibrillation, etc.), coronary stent implantation, angioplasty or coronary artery bypass grafting);
8. Accompanying diseases that the investigator believes the investigational drug may cause unnecessary risks of, such as: severe cardiovascular and cerebrovascular diseases, digestive system diseases, liver and kidney dysfunction diseases, or a family history of mental illness;
9. Laboratory examination abnormalities during the screening period (baseline), such as:

   1. Blood biochemistry: alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin ≥ 3 times the upper limit of normal (ULN) (if liver metastasis exists, ALT, AST, total bilirubin can be ≥ 5 × ULN); serum creatinine ≥ 1.5 × ULN;
   2. Blood routine: absolute neutrophil value \<1.5×10\^9/L; hemoglobin \< 80 g/L;
10. Abnormal electrocardiogram of clinical significance during screening or prolonged QT/QTc interval, such as QTcF ≥ 450ms (male) or 470ms (female); family history of QT prolongation;
11. Active hepatitis B (hepatitis B virus titer \> 1,000 copies/ml or 200IU/ml); hepatitis C virus infection (HCV-RNA Above the detection limit); preventive antiviral treatment other than interferon is allowed. For patients with hepatocellular carcinoma (HCC), hepatitis B virus titer\> 10,000 copies/ml or 2000IU/ml; human immunodeficiency virus antibody (HIV), syphilis positive;
12. Received platelet transfusion within 5 days before the first dose;
13. Anticoagulants (heparin, warfarin, apixaban, bivalirudin, etc.), antiplatelet drugs (clopidogrel, aspirin, etc.), fibrinolytic drugs (urokinase, etc.) were used for prevention or treatment within 1 week before the first dose;
14. Received other drugs with platelet-raising effects (e.g., caffeic acid tablets, leucogen tablets, aminopeptide tablets, or platelet-raising capsules, etc.) within 1 week before the first dose; received recombinant human thrombopoietin (rh-TPO) or used recombinant human interleukin-11 (rhIL-11), thrombopoietin receptor agonist (TPO-RA) within 10 days before the first dose or 5 half-lives of the drug (whichever is longer);
15. Currently receiving or received radiotherapy within 3 months before screening;
16. Received bone marrow transplantation or stem cell infusion within 1 year before screening;
17. Allergic to the investigational drug or excipients (such as histidine, glycine, mannitol, sucrose) or previously experienced life-threatening systemic allergic reaction;
18. Used other clinical trial drugs or devices within 4 weeks before the first dose;
19. Other conditions the investigator believes would be unsuitable for participation in this clinical study.

Where this trial is running

Baoding, Hebei and 5 other locations

• Affiliated Hospital of Hebei University — Baoding, Hebei, China (RECRUITING)
• The First Affiliated Hospital of Henan University of Science and Technology — Luoyang, Henan, China (RECRUITING)
• Henan Cancer Hospital — Zhengzhou, Henan, China (RECRUITING)
• Yiyang Central Hospital — Yiyang, Hunan, China (RECRUITING)
• The Affiliated Hospital of Qingdao University — Qingdao, Shandong, China (RECRUITING)
• Affiliated Hospital of Southwest Medical University — Luzhou, Sichuan, China (RECRUITING)

Study contacts

• Principal investigator: Suxia Luo — Henan Cancer Hospital
• Study coordinator: Jing Sun

Conditions: Thrombocytopenia