Preventing kidney injury after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effectiveness of Coenzyme Q10 and Glutathione in preventing acute kidney injury (AKI) in patients undergoing elective cardiac surgery with cardiopulmonary bypass. A total of 242 participants will be randomly assigned to receive either the active treatment or a placebo, starting the day before surgery and continuing for up to one week post-operation. Blood and urine samples will be collected to monitor kidney function and any adverse effects related to the treatments. The study aims to address the high incidence of AKI following cardiac surgery, which can lead to severe complications and long-term health issues.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult 18-70 years of age
* Undergoing elective CPB (Cardiopulmonary Bypass) surgery
* Baseline GFR (Glomerular Filtration Rate) ≥45 ml/min

Exclusion Criteria:

* GFR (Glomerular Filtration Rate) \<45 ml/min
* Solitary kidney
* Status post-kidney transplant
* Pregnant women
* Allergy to CoQ10
* Allergy to Glutathione
* Allergy to Cellulose

Where it's running

• George Washington University Hospital
  Washington D.C., District of Columbia, United States Recruiting

Study contacts

• Principal investigator: Yoosif Abdalla, MD — George Washington University
• Study coordinator: Eduard Shaykhinurov, MS
• Email: eshaykhinurov@mfa.gwu.edu
• Phone: 2028234259

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.