Preventing blood clots in patients undergoing varicose vein treatment
Official title: THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE) - a Multi-centre Assessor-blind Randomised-controlled Trial
Run by Imperial College London · NCT05735639 · Data updated 2026-11-12
This study tests different blood-thinning medications to see which one best helps prevent blood clots in adults getting treatment for varicose veins.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 3175 (estimated) |
| Sponsor | Imperial College London Academic / other |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | January 22, 2024 |
| Main results expected | June 30, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | June 4, 2026 |
| Trial ID | NCT05735639 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 scheduled for endovenous interventions for truncal varicose veins under local anesthesia.
✕Probably not a fit
Patients with a history of venous thromboembolism, certain bleeding disorders, or those requiring therapeutic anticoagulation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of various anticoagulants in preventing venous thromboembolism (VTE) in adults undergoing endovenous interventions for truncal varicose veins. The research focuses on patients scheduled for minimally invasive procedures such as radiofrequency, laser, and sclerotherapy, which may increase the risk of blood clots. By comparing different anticoagulant treatments, the study aims to determine the best approach to reduce the incidence of VTE following these procedures.
Why it matters
Potential benefit: If successful, this study could significantly reduce the risk of blood clots in patients undergoing varicose vein treatments, improving patient safety and outcomes.
How similar studies have gone: Other studies have shown varying success with anticoagulant use in similar surgical contexts, but this specific approach is still being evaluated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (\>18 years) * Scheduled to undergo endovenous intervention of truncal varicose veins under local anaesthesia * Treatment technologies including radiofrequency, laser, mechanochemical, foam sclerotherapy and cyanoacrylate glue Exclusion Criteria: * Clinical indication for therapeutic anticoagulation e.g., atrial fibrillation * Previous personal or first-degree relative history of VTE * Thrombophilia * Female patients of childbearing potential who have a positive pregnancy test * A history of allergy to heparins or direct oral anticoagulants * A history of heparin-induced thrombocytopenia * Inherited and acquired bleeding disorders * Evidence of active bleeding * Concomitant major health problems such as active cancer and chronic renal and/or liver impairment * Known thrombocytopenia (platelets known to be less than 50 x 109 /l) * Surgery or major trauma in the previous 90 days * Recent ischemic stroke in the previous 90 days * Inability to provide consent
Where it's running
-
Imperial College Hospital NHS Foundation Trust
London, United Kingdom Recruiting
Study contacts
- Study coordinator: Sarah Whittley
- Email: s.whittley@imperial.ac.uk
- Phone: +442033117309
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.