Preserving fertility in girls before cancer treatment
Female Fertility Preservation Using Ovarian Tissue Cryopreservation Before Highly Gonadotoxic Cancer Treatment
This study is testing whether freezing ovarian tissue can help young girls at risk of losing their fertility due to cancer treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 2 Months to 18 Years |
| Sex | Female |
| Sponsor | University Hospital, Geneva Academic / other |
| Locations | 2 sites (Geneva and 1 other locations) |
| Trial ID | NCT03180827 on ClinicalTrials.gov |
What this trial studies
This study focuses on the cryopreservation of ovarian tissue in prepubertal and peripubertal girls who are at high risk of infertility due to gonadotoxic cancer treatments. The primary aim is to collect and preserve ovarian tissue before the onset of such treatments, which can include high doses of alkylating agents or radiation. Additionally, the study aims to create a database for clinical and biological follow-up data and collaborate with the Fertisave Registry to pool resources. This approach is particularly important as it offers a potential solution for preserving fertility in young cancer patients.
Who should consider this trial
Good fit: Ideal candidates for this study are pediatric patients aged 2 months and older who are at high risk of infertility due to gonadotoxic treatments.
Not a fit: Patients under the age of 2 months or those whose treatments are not highly gonadotoxic may not benefit from this study.
Why it matters
Potential benefit: If successful, this could provide a viable option for preserving fertility in young girls undergoing cancer treatment.
How similar studies have performed: Other studies have shown promise in fertility preservation techniques, but this specific approach of ovarian tissue cryopreservation in young girls is still considered novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pediatric pre ou peripubertal patient aged 2 months and older * Patient presenting high risk of infertility because of gonadotoxic treatments (i.e. high dose of alkylating agents, ovarian irradiation, total body irradiation) * Multidisciplinary team consensus in favour to proposition to cryopreserve ovarian tissue. Exclusion Criteria: * Patient under the age of 2 months * Refusal of the patient and/or her parents * Treatments that are not highly gonadotoxic
Where this trial is running
Geneva and 1 other locations
- Geneva University Hospitals — Geneva, Switzerland (Recruiting)
- Chuv — Lausanne, Switzerland (Recruiting)
Study contacts
- Study coordinator: Fabienne Gumy-Pause, Dr
- Email: fabienne.gumypause@hcuge.ch
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.