Preserving fertility in boys undergoing cancer treatment
Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment
This study is testing a way to help young boys with cancer keep their ability to have children in the future by freezing their testicular tissue before treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 3 Months to 18 Years |
| Sex | Male |
| Sponsor | University Hospital, Geneva Academic / other |
| Locations | 3 sites (Basel and 2 other locations) |
| Trial ID | NCT03180918 on ClinicalTrials.gov |
What this trial studies
This study focuses on preserving fertility in prepubertal boys who are at risk of infertility due to highly gonadotoxic cancer treatments. It involves the cryopreservation of testicular tissue through biopsy, allowing for the potential future restoration of fertility. The study also aims to create a database for clinical and biological follow-up data and establish a biobank for future research. It is a multicentric effort involving several hospitals in Switzerland.
Who should consider this trial
Good fit: Ideal candidates include prepubertal boys aged 3 months and older and peri-pubertal patients who have failed sperm cryopreservation and are at high risk of infertility.
Not a fit: Patients under the age of 3 months or those whose treatments are not highly gonadotoxic may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could help preserve fertility for young boys facing cancer treatments, offering them hope for future parenthood.
How similar studies have performed: Other studies have explored fertility preservation in cancer patients, but this specific approach of testicular tissue cryopreservation in prepubertal boys is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Prepubertal patients aged 3 months and older * Peri and pubertal patients after failure of sperm cryopreservation * Patients presenting high risk of infertility because of gonadotoxic treatments (i.e high dose of alkylating agents, testicular irradiation, total body irradiation). * Multidisciplinary team consensus in favour of proposition to cryopreserve testicular tissue Exclusion Criteria: * Patients under the age of 3 months * Refusal of the patient and/or his parents * Treatments that are not highly gonadotoxic
Where this trial is running
Basel and 2 other locations
- Ukbb — Basel, Switzerland (Recruiting)
- Geneva University Hospitals — Geneva, Switzerland (Recruiting)
- Chuv — Lausanne, Switzerland (Recruiting)
Study contacts
- Study coordinator: Fabienne Gumy-Pause, Dr
- Email: fabienne.gumypause@hcuge.ch
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.