Preoperative IV dexamethasone to reduce pain after minimally invasive lumbar fusion (MIS-TLIF)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional Phase 4 trial compares a preoperative intravenous dose of dexamethasone with normal saline given before minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). Participants are patients aged 50–80 undergoing MIS-TLIF at one or two spinal levels and who meet metabolic and medication-related eligibility criteria. Primary outcomes focus on postoperative back pain, with secondary outcomes including opioid (morphine) consumption and other recovery metrics. The design uses a preemptive single injection to test whether adding dexamethasone to standard ERAS medications can further reduce pain and shorten recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age range: 50-80 years old.
* Undergoing MIS TLIF surgery at 1-2 spinal levels.

Exclusion Criteria:

* Previously undergone spine surgery.
* HbA1C greater than or equal to 7.5 mg%
* Allergic to all types of experimental medication.
* History of using systemic steroids.

Where it's running

• Thammasat university hospital
  Pathum Thani, Changwat Pathum Thani, Thailand Recruiting

Study contacts

• Study coordinator: Konthorn Chankong, Master's degree
• Email: gearkonthorn@gmail.com
• Phone: +66859496902

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.