Preoperative intestinal training with antegrade ileostomy infusion
Official title: Pilot Study of Preoperative Intestinal Training Using Antegrade Ileostomy Infusion
Run by University of California, San Diego · NCT06461559 · Data updated 2026-11-12
This trial will try infusing material from your ostomy bag back into your unused intestine before reversal surgery to see if it helps the bowel recover faster for people with a diverting loop ileostomy.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University of California, San Diego Academic / other |
| Locations | 1 site (La Jolla, California) |
| Status | Recruiting |
| Started | August 1, 2024 |
| Main results expected | March 1, 2026 |
| Study ends | May 1, 2026 |
| Registry record updated | December 15, 2025 |
| Trial ID | NCT06461559 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with a diverting loop ileostomy who are scheduled for takedown and who can give consent and perform or tolerate the stoma infusion procedure.
✕Probably not a fit
Patients who cannot consent, cannot perform or tolerate stoma infusion, or who have conditions that make reversal unlikely or unsafe are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This Phase 1/2 pilot enrolls patients with a diverting loop ileostomy who are being evaluated for stoma takedown at UC San Diego. Participants receive antegrade infusion of ostomy effluent into the distal intestine in the weeks before their planned reversal operation to 're-train' the bowel. The study will track safety, feasibility, and early signals of faster return of normal bowel function and fewer post-operative complications. Findings will inform whether a larger trial is warranted.
Why it matters
Potential benefit: If successful, this approach could speed recovery of normal bowel function after ostomy reversal and reduce post-operative symptoms and complications.
How similar studies have gone: The idea of re-exposing unused bowel to enteric contents is relatively novel; small case series and physiologic studies suggest feasibility but randomized evidence is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Has a diverting loop ileostomy * undergoing evaluation for stoma takedown Exclusion Criteria: * unable to perform consent * unable to perform stoma infusion
Where it's running
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UC San Diego
La Jolla, California, United States Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.