Prenatal prevention and treatment strategy for neonatal ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers built a prenatal prediction model using multivariable logistic regression and presented it as a nomogram to identify pregnancies at high risk for neonatal ARDS. Pregnant women with a predicted risk greater than 80% who consent will receive at least one dose of dexamethasone before delivery, with a comparison group not receiving the intervention. Cord blood glucocorticoid levels and mRNA expression of α-ENaC, Na-K-ATPase, and SGK1 in neonatal nasal epithelium will be measured within 2 hours and at 24 hours after birth, and lung ultrasound will be used to document pulmonary edema, ARDS occurrence and severity, and mortality. The project links molecular markers of lung fluid clearance with clinical outcomes to see if targeted antenatal steroid use can prevent or lessen NARDS in near-term and full-term infants.

Why it matters

Who can join: the full rules

A predictive model for neonatal acute respiratory distress syndrome was established based on perinatal risk factors.

Inclusion Criteria:

1. The pregnant women with a probability greater than 80% in the prediction model of neonatal acute respiratory distress syndrome and agreed to ACS intervention.
2. Obtaining patient consent.

Exclusion Criteria:

1. the pregnant women with a probability of less than 80% in the neonatal acute respiratory distress syndrome prediction model.
2. The patient refuses.

Where it's running

• The Second Affiliated Hospital of Chongqing Medical University
  Chongqing, China Recruiting

Study contacts

• Study coordinator: Li Wang, MD,PhD
• Email: liwang8771@126.com
• Phone: 13527499258

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Human umbilical cord mesenchymal stem cell injection for moderate to severe ARDS

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  Recruiting Phase 1/2 Changchun Tuohua Pharmaceutical Co., Ltd. · Wuhan, Hubei · NCT07413978

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.