Home › Trials › NCT07681466
Clinical trial Recruiting at 1 site Observational Ages 18 to 65

Premonitory migraine symptoms: how they unfold before a headache

Official title: Chronology and Sequence of Premonitory Symptoms to Understand How Migraine Attack Starts: the CHRONOpS Study

Run by University of Roma La Sapienza · NCT07681466 · Data updated 2026-11-12

This study tests how premonitory symptoms appear in sequence before migraine attacks in adults with episodic or chronic migraine.

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment500 (estimated)
SponsorUniversity of Roma La Sapienza
Academic / other
Locations1 site (Latina, Italy)
StatusRecruiting
StartedMarch 17, 2026
Main results expectedMarch 2027
Study endsSeptember 2027
Registry record updatedJuly 2, 2026
Trial IDNCT07681466 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–65 with episodic or chronic migraine (including MOH) who have at least 2 migraine days per month and a migraine history of at least 12 months.

Probably not a fit

Individuals without frequent migraine episodes or with recent onset (<12 months) may not experience benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to map the order and timing of early migraine symptoms that occur before head pain. Researchers will prospectively track premonitory signs across multiple migraine episodes to understand their chronology. The project seeks to link symptom sequences with brain activity patterns and escalation toward the headache phase. Participants must have migraine for at least a year, be 18–65, and experience multiple migraine days per month. Data will help refine how premonitory phases are recognized and potentially managed.

Why it matters

Potential benefit: Understanding the sequence of premonitory symptoms could lead to earlier identification and timely treatment of migraine attacks.

How similar studies have gone: Previous imaging and clinical work have shown hypothalamic involvement in the premonitory phase, but prospective sequencing in humans remains limited; this study extends that work.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Diagnosis of episodic (EM) or chronic migraine (CM) or CM with medication overuse headache (MOH) according to ICHD-III criteria;
* Age between 18 and 65 years;
* At least 2 migraine days (MMD) in the month preceding the inclusion;
* Migraine history of at least 12 months prior to inclusion
* Signed written informed consent.

Exclusion Criteria:

* History or current diagnosis of secondary headache disorders as defined by ICHD-III;
* History of other neurological comorbidities or major psychiatric disorders;
* History of migraine for \< 12 months prior to the inclusion;
* Opioid overuse according to the ICHD-III criteria;
* Pregnancy or breastfeeding.

Where it's running

  • Sapienza University of Rome, Polo Pontino, centro cefalee, ICOT
    Latina, Italy, Italy     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
Browse more
Migraine 167University of Roma La Sapienza 24
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.